methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]phenoxyacetate

Base Information

• Chemical Name: methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]phenoxyacetate
• CAS No.: 140849-98-5
• Molecular Formula: C₂₀H₂₅NO₅
• Molecular Weight: 359.422
• Mol file: 140849-98-5.mol

Synonyms:methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]phenoxyacetate

Chemical Property of methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]phenoxyacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]phenoxyacetate

There total 5 articles about methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]phenoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-[2-(N-benzyl-N-(2-hydroxy-3-phenoxypropyl)amino)ethyl]phenoxyacetate (125794-20-9) → methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]phenoxyacetate (140849-98-5)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; at 60 ℃; for 48h; under 15001.2 Torr;

DOI:10.1021/jm00088a010

Reference yield:

tyrosamine (51-67-2) → methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]phenoxyacetate (140849-98-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 2.) NaBH₄ / 1.) EtOH, RT, 1.5 h, 2.) EtOH, RT, 3 h

2: propan-2-ol / 72 h / Heating

3: K₂CO₃, KI / acetone / 24 h / Heating

4: H₂, AcOH / 10percent Pd/C / methanol / 48 h / 60 °C / 15001.2 Torr

With sodium tetrahydroborate; hydrogen; potassium carbonate; acetic acid; potassium iodide; palladium on activated charcoal; In methanol; isopropyl alcohol; acetone;

DOI:10.1021/jm00088a010

Reference yield:

N-benzyltyramine (52447-50-4) → methyl 4-[2-(2-hydroxy-3-phenoxypropylamino)ethyl]phenoxyacetate (140849-98-5)

Guidance literature:

Multi-step reaction with 3 steps

1: propan-2-ol / 72 h / Heating

2: K₂CO₃, KI / acetone / 24 h / Heating

3: H₂, AcOH / 10percent Pd/C / methanol / 48 h / 60 °C / 15001.2 Torr

With hydrogen; potassium carbonate; acetic acid; potassium iodide; palladium on activated charcoal; In methanol; isopropyl alcohol; acetone;

DOI:10.1021/jm00088a010

upstream raw materials:

methyl 4-[2-(N-benzyl-N-(2-hydroxy-3-phenoxypropyl)amino)ethyl]phenoxyacetate

tyrosamine

Phenyl glycidyl ether

N-benzyltyramine