3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl) 2-(2-fluorobenzyl)-N-methyl-N-cyclopropylpropanamide

Base Information

• Chemical Name: 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl) 2-(2-fluorobenzyl)-N-methyl-N-cyclopropylpropanamide
• CAS No.: 1378389-85-5
• Molecular Formula: C₂₅H₃₀F₂N₂O₂S
• Molecular Weight: 460.588
• Mol file: 1378389-85-5.mol

Synonyms:3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl) 2-(2-fluorobenzyl)-N-methyl-N-cyclopropylpropanamide

Chemical Property of 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl) 2-(2-fluorobenzyl)-N-methyl-N-cyclopropylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl) 2-(2-fluorobenzyl)-N-methyl-N-cyclopropylpropanamide

There total 1 articles about 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl) 2-(2-fluorobenzyl)-N-methyl-N-cyclopropylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoic acid trifluoroacetate (1307250-00-5) + methylcyclopropylamine hydrochloride (67376-94-7) → 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl) 2-(2-fluorobenzyl)-N-methyl-N-cyclopropylpropanamide (1378389-85-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jm201629q

Reference yield:

3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl) 2-(2-fluorobenzyl)-N-methyl-N-cyclopropylpropanamide (1378389-85-5) → 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl) 2-(2-fluorobenzyl)-N-methyl-N-cyclopropylpropanamide + 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl) 2-(2-fluorobenzyl)-N-methyl-N-cyclopropylpropanamide

Guidance literature:

With CAPCELL PAK C₁₈ MG column; In water; acetonitrile; trifluoroacetic acid; at 45 ℃; Resolution of racemate;

DOI:10.1021/jm201629q

upstream raw materials:

2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoic acid trifluoroacetate

methylcyclopropylamine hydrochloride