Technology Process of 2-ethyl-5-(L-phenylalanyl)-amino benzimidazole
There total 5 articles about 2-ethyl-5-(L-phenylalanyl)-amino benzimidazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-ethyl-5-(phthaloyl-L-phenylalanyl)-amino benzimidazole;
With
hydrazine hydrate;
In
ethanol;
for 1h;
Reflux;
With
hydrogenchloride;
In
water;
at 50 ℃;
for 0.166667h;
DOI:10.5012/jkcs.2011.55.4.650
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; zinc / water / 1 h / Reflux
2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 0.42 h / 0 °C
3.1: hydrazine hydrate / ethanol / 1 h / Reflux
3.2: 0.17 h / 50 °C
With
hydrogenchloride; sodium hydrogencarbonate; hydrazine hydrate; zinc;
In
1,4-dioxane; ethanol; water;
DOI:10.5012/jkcs.2011.55.4.650
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 0.5 h / 140 - 150 °C
2.1: phosphorus pentachloride / benzene / 2 h / 50 °C
3.1: sodium hydrogencarbonate / 1,4-dioxane; water / 0.42 h / 0 °C
4.1: hydrazine hydrate / ethanol / 1 h / Reflux
4.2: 0.17 h / 50 °C
With
phosphorus pentachloride; sodium hydrogencarbonate; hydrazine hydrate;
In
1,4-dioxane; ethanol; water; benzene;
DOI:10.5012/jkcs.2011.55.4.650
