t-butyl O-methyl-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

Base Information

Chemical Name:t-butyl O-methyl-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate
CAS No.:216502-87-3
Molecular Formula:C₂₁H₂₅F₃N₂O₅S
Molecular Weight:474.501
Hs Code.:

Synonyms:t-butyl O-methyl-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

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Chemical Property of t-butyl O-methyl-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

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Technology Process of t-butyl O-methyl-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

There total 6 articles about t-butyl O-methyl-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 216502-86-2
(S)-3-(4-Methoxy-3-nitro-phenyl)-2-(3-trifluoromethyl-benzenesulfonylamino)-propionic acid tert-butyl ester

: 216502-87-3
t-butyl O-methyl-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

Guidance literature:: With hydrogen; platinum(IV) oxide; In methanol; at 20 ℃; for 17h; under 2068.6 Torr;
DOI:10.1016/S0968-0896(98)00083-2

Reference yield:

: 777-44-6
3-(Trifluoromethyl)benzenesulfonyl chloride

: 216502-87-3
t-butyl O-methyl-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

Guidance literature:: Multi-step reaction with 2 steps

1: 51 percent / Et₃N / CH₂Cl₂ / 20 h / 20 °C

2: 91 percent / H₂ / PtO₂ / methanol / 17 h / 20 °C / 2068.6 Torr

With hydrogen; triethylamine; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(98)00083-2

Reference yield:

: 16874-12-7,87553-74-0
Tyr(tBu)

: 216502-87-3
t-butyl O-methyl-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) conc. HNO₃, AcOH / 1.) room temperature, 30 min, 2.) 10-14 deg C, 75 min

2: 72 percent / K₂CO₃, <18-c-6>crown-ether / acetonitrile / 48 h / Heating

3: 88 percent / K₂CO₃ / methanol; H₂O / 17 h / 20 °C

4: 51 percent / Et₃N / CH₂Cl₂ / 20 h / 20 °C

5: 91 percent / H₂ / PtO₂ / methanol / 17 h / 20 °C / 2068.6 Torr

With 18-crown-6 ether; hydrogen; nitric acid; potassium carbonate; acetic acid; triethylamine; platinum(IV) oxide; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0968-0896(98)00083-2