Technology Process of Toluene-4-sulfonic acid (3Z,6Z)-8-(2,2-dimethyl-[1,3]dioxolan-4-yl)-octa-3,6-dienyl ester
There total 7 articles about Toluene-4-sulfonic acid (3Z,6Z)-8-(2,2-dimethyl-[1,3]dioxolan-4-yl)-octa-3,6-dienyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / KOH / diethyl ether / 4 h
2: EtMgBr, CuBr*Me2S / tetrahydrofuran / 1.) 50 deg C, 30 min; 0 deg C, 5 min, 2.) 0 deg C to r.t., 10 h
3: 1.) K3Fe(CN)6, K2CO3, OsO4, H2O, 2.) Dowex 50 x 8 - 100 ion-exchange resin / 1.) t-BuOH, r.t., 48 h, 2.) MeOH, r.t., 13 h
4: conc. H2SO4, molecular sieves 4A, Na2SO4 / 13 h / Ambient temperature
5: 87 percent / H2, ethylenediamine / P-2 Ni catalyst / ethanol / 5 h / 23 °C
6: 82 percent / pyridine / CH2Cl2 / 8 h / 0 °C
With
pyridine; potassium hydroxide; osmium(VIII) oxide; copper(I) bromide dimethylsulfide complex; 4 A molecular sieve; Dowex 50 x 8 - 100 ion-exchange resin; sulfuric acid; ethylmagnesium bromide; water; hydrogen; potassium carbonate; sodium sulfate; ethylenediamine; potassium hexacyanoferrate(III);
P-2 Ni catalyst;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo00106a026
- Guidance literature:
-
Multi-step reaction with 3 steps
1: conc. H2SO4, molecular sieves 4A, Na2SO4 / 13 h / Ambient temperature
2: 87 percent / H2, ethylenediamine / P-2 Ni catalyst / ethanol / 5 h / 23 °C
3: 82 percent / pyridine / CH2Cl2 / 8 h / 0 °C
With
pyridine; 4 A molecular sieve; sulfuric acid; hydrogen; sodium sulfate; ethylenediamine;
P-2 Ni catalyst;
In
ethanol; dichloromethane;
DOI:10.1021/jo00106a026
