1,3-Diaminopropane hydrochloride

Base Information

• Chemical Name: 1,3-Diaminopropane hydrochloride
• CAS No.: 10517-44-9
• Molecular Formula: C3H10 N2 . 2 Cl H
• Molecular Weight: 147.048
• Hs Code.: 2921290000
• Mol file: 10517-44-9.mol

Synonyms:1,3-Diaminopropane hydrochloride;SCHEMBL158471;MFMLMKLBWODGNA-UHFFFAOYSA-N;propane-1,3-diamine hydrochloride;AKOS015894769

Chemical Property of 1,3-Diaminopropane hydrochloride

Chemical Property:

• Vapor Pressure: 7.7mmHg at 25°C
• Melting Point: 246-250 °C(lit.)
• Boiling Point: 135.5°Cat760mmHg
• Flash Point: 48.9°C
• PSA: 52.04000
• Density: 0.867g/cm³
• LogP: 2.29850
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 110.0610761
• Heavy Atom Count: 6
• Complexity: 12.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,3-Diaminopropane Dihydrochloride (Low water content) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-36-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CN)CN.Cl
• Uses: 1,3-Diaminopropane Dihydrochloride (Low water content) is the Chlorinated form of 1,3-Diaminopropane(D416660) is a common chemical reagent, used in the synthesis of 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors applied in the treatment of Alzheimer’s disease. Also used in the synthesis of thrombosis inhibitors.

Technology Process of 1,3-Diaminopropane hydrochloride

There total 6 articles about 1,3-Diaminopropane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Trimethylenediamine (109-76-2,54018-94-9) → 1,3-diaminopropane dihydrochloride (10517-44-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; for 0.166667h;

DOI:10.1002/chem.201902556

Reference yield: 95.0%

3-azidopropylamine (88192-19-2) → 1,3-diaminopropane dihydrochloride (10517-44-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 18h; under 3102.9 Torr; Ambient temperature;

DOI:10.1055/s-1996-4438

Reference yield: 77.0%

Trimethylenediamine (109-76-2,54018-94-9) + acryloyl chloride (814-68-6,25189-84-8) → N,N'-bisacrylyl-1,3-diaminopropane (4887-13-2) + 1,3-diaminopropane dihydrochloride (10517-44-9)

Guidance literature:

In acetonitrile; for 2h; Ambient temperature;

upstream raw materials:

1,5-Diazacyclooctadecan-6,18-dion

Trimethylenediamine

acryloyl chloride

3-azidopropylamine

Downstream raw materials:

1,1'-(propane-1,3-diyl)diguanidine

Terephthalic acid; compound with propane-1,3-diamine

Phthalic acid; compound with propane-1,3-diamine

hexahydropyrimidine

Refernces

• 1、 Khoukhi, Mostafa,Vaultier, Michel,Benalil, Aziza,Carboni, Bertrand. "Curtius rearrangement of ω-azido acid chlorides: Access to the corresponding ω-azido substituted amines and carbamates, useful building blocks for polyamine syntheses". . p. 483 - 487. Retrieved 1996.
• 2、 Koch,Ognyanov,Hesse. "Synthesis of macrocycles by ring enlargement of 14-membered cyclic imides". . p. 62 - 68. Retrieved 2007/10/02.