2-(1H-1,2,3,4-benzotriazol-1-ylmethyl)-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Base Information

• Chemical Name: 2-(1H-1,2,3,4-benzotriazol-1-ylmethyl)-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole
• CAS No.: 561305-29-1
• Molecular Formula: C₁₉H₁₉N₅
• Molecular Weight: 317.393

Synonyms:2-(1H-1,2,3,4-benzotriazol-1-ylmethyl)-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Chemical Property of 2-(1H-1,2,3,4-benzotriazol-1-ylmethyl)-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Chemical Property:

Purity/Quality:

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Technology Process of 2-(1H-1,2,3,4-benzotriazol-1-ylmethyl)-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole

There total 1 articles about 2-(1H-1,2,3,4-benzotriazol-1-ylmethyl)-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methylindole (83-34-1) → 2-(1H-1,2,3,4-benzotriazol-1-ylmethyl)-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole (561305-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH; tetrabutylammonium hydrogen sulfate / acetonitrile / 36 h / Heating

2: 96 percent / methanol; H₂O / 25 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In methanol; water; acetonitrile;

DOI:10.1016/j.bmc.2005.11.054

Reference yield: 95.0%

para-methylphenylmagnesium bromide (4294-57-9) + 2-(1H-1,2,3,4-benzotriazol-1-ylmethyl)-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole (561305-29-1) → 2-(4-methylbenzyl)-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Guidance literature:

In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jo026922x

Reference yield: 93.0%

phenylmagnesium bromide + 2-(1H-1,2,3,4-benzotriazol-1-ylmethyl)-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole (561305-29-1) → 2-benzyl-10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole

Guidance literature:

In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jo026922x

upstream raw materials:

3-Methylindole

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