2-(4-methyl)phenyl-4'-(5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)benzanilide

Base Information

• Chemical Name: 2-(4-methyl)phenyl-4'-(5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)benzanilide
• CAS No.: 168626-55-9
• Molecular Formula: C₃₁H₂₆N₂O₃
• Molecular Weight: 474.559

Synonyms:2-(4-methyl)phenyl-4'-(5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)benzanilide

Chemical Property of 2-(4-methyl)phenyl-4'-(5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)benzanilide

Chemical Property:

Purity/Quality:

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Technology Process of 2-(4-methyl)phenyl-4'-(5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)benzanilide

There total 2 articles about 2-(4-methyl)phenyl-4'-(5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)benzanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

o-tolylbenzoic acid (7148-03-0) → 2-(4-methyl)phenyl-4'-(5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)benzanilide (168626-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride, N,N-dimethylformamide / CH₂Cl₂ / 4 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1248/cpb.47.329

Reference yield:

4'-methylbiphenyl-2-carboxylic acid chloride (114772-35-9) + 1-(4-aminobenzoyl)-2,3,4,5-tetrahydro1H-1-benzazepin-5-one (137976-09-1) → 2-(4-methyl)phenyl-4'-(5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)benzanilide (168626-55-9)

Guidance literature:

With triethylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1248/cpb.47.329

Reference yield:

2-(4-methyl)phenyl-4'-(5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)benzanilide (168626-55-9) → 4'-[(2-amino-5,6-dihydro-4H-thiazolo[5,4-d][1]benzazepin-6-yl)carbonyl]-2-(4-methylphenyl)benzanilide

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate;

upstream raw materials:

4'-methylbiphenyl-2-carboxylic acid chloride

1-(4-aminobenzoyl)-2,3,4,5-tetrahydro1H-1-benzazepin-5-one

o-tolylbenzoic acid

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