(1RS)-1-[(RS)-(5-chloro-6,7-dimethoxy-1-methyl-indol-3-yl)-hydroxy-methyl]-3ξ-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

Base Information

Chemical Name:(1RS)-1-[(RS)-(5-chloro-6,7-dimethoxy-1-methyl-indol-3-yl)-hydroxy-methyl]-3ξ-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione
CAS No.:50801-18-8
Molecular Formula:C₂₆H₂₈ClN₃O₆S₂
Molecular Weight:578.11
Hs Code.:

(1<i>RS</i>)-1-[(<i>RS</i>)-(5-chloro-6,7-dimethoxy-1-methyl-indol-3-yl)-hydroxy-methyl]-3ξ-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

Synonyms:(1RS)-1-[(RS)-(5-chloro-6,7-dimethoxy-1-methyl-indol-3-yl)-hydroxy-methyl]-3ξ-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

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Chemical Property of (1RS)-1-[(RS)-(5-chloro-6,7-dimethoxy-1-methyl-indol-3-yl)-hydroxy-methyl]-3ξ-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

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Technology Process of (1RS)-1-[(RS)-(5-chloro-6,7-dimethoxy-1-methyl-indol-3-yl)-hydroxy-methyl]-3ξ-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

There total 6 articles about (1RS)-1-[(RS)-(5-chloro-6,7-dimethoxy-1-methyl-indol-3-yl)-hydroxy-methyl]-3ξ-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50627-48-0,50763-62-7
1-(5-chloro-6,7-dimethoxy-1-methyl-indole-3-carbonyl)-3-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

: 50801-18-8
(1RS)-1-[(RS)-(5-chloro-6,7-dimethoxy-1-methyl-indol-3-yl)-hydroxy-methyl]-3ξ-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ja00800a079

Reference yield:

: 50627-46-8
5-chloro-6,7-dimethoxy-1-methyl-indole-3-carbonyl chloride

: 50801-18-8
(1RS)-1-[(RS)-(5-chloro-6,7-dimethoxy-1-methyl-indol-3-yl)-hydroxy-methyl]-3ξ-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

Guidance literature:: Multi-step reaction with 3 steps

1: (i) BuLi, (ii) /BRN= 418289/, THF

2: hydrogenchloride; trifluoroacetic acid

3: diisobutylaluminium hydride / tetrahydrofuran / -78 °C

With hydrogenchloride; diisobutylaluminium hydride; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/ja00800a079

Reference yield:

: 50627-41-3
3-acetylsulfanyl-4-methoxymethyl-1-methyl-6-methylene-piperazine-2,5-dione

: 50801-18-8
(1RS)-1-[(RS)-(5-chloro-6,7-dimethoxy-1-methyl-indol-3-yl)-hydroxy-methyl]-3ξ-(4-methoxy-phenyl)-5,6-dimethyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione

Guidance literature:: Multi-step reaction with 4 steps

1: (i) aq. HCl, MeOH, (ii) /BRN= 98362/, BF₃-Et₂O, CH₂Cl₂

2: (i) BuLi, (ii) /BRN= 418289/, THF

3: hydrogenchloride; trifluoroacetic acid

4: diisobutylaluminium hydride / tetrahydrofuran / -78 °C

With hydrogenchloride; diisobutylaluminium hydride; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/ja00800a079