4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)-1,2,3,4-tetrahydropyridine

Base Information

Chemical Name:4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)-1,2,3,4-tetrahydropyridine
CAS No.:1433190-42-1
Molecular Formula:C₂₄H₃₁NO₂
Molecular Weight:365.516
Hs Code.:

Synonyms:4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)-1,2,3,4-tetrahydropyridine

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Chemical Property of 4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)-1,2,3,4-tetrahydropyridine

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Technology Process of 4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)-1,2,3,4-tetrahydropyridine

There total 1 articles about 4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)-1,2,3,4-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 494199-22-3
4-(2,5-dimethoxyphenyl)-1-methyl-1,2,3,6-tetrahydropyridine

: 13633-25-5
1-Bromo-4-phenylbutane

: 1433190-42-1
4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)-1,2,3,4-tetrahydropyridine

Guidance literature:: 4-(2,5-dimethoxyphenyl)-1-methyl-1,2,3,6-tetrahydropyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -20 ℃; for 2h; Inert atmosphere;

1-Bromo-4-phenylbutane; In tetrahydrofuran; hexane; at -20 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.02.060

Reference yield: 85.0%

: 1433190-42-1
4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)-1,2,3,4-tetrahydropyridine

: 3-bromo-4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)piperidine

Guidance literature:: 4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)-1,2,3,4-tetrahydropyridine; With N-Bromosuccinimide; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; sodium cyanoborohydride; In methanol; water; at 20 ℃; for 0.5h;
DOI:10.1016/j.bmc.2013.02.060

Reference yield:

: 1433190-42-1
4-(2,5-dimethoxyphenyl)-1-methyl-4-(4-phenylbutyl)-1,2,3,4-tetrahydropyridine

: 2-(3-bromo-1-methyl-4-(4-phenylbutyl)piperidin-4-yl)benzene-1,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: hydrogen bromide / 10 h / Reflux

With N-Bromosuccinimide; hydrogen bromide; In tetrahydrofuran;
DOI:10.1016/j.bmc.2013.02.060