2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetimidamide hydrochloride

Base Information

Chemical Name:2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetimidamide hydrochloride
CAS No.:1417917-75-9
Molecular Formula:C₁₉H₂₆N₄O₃*ClH
Molecular Weight:394.901
Hs Code.:

Synonyms:2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetimidamide hydrochloride

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Chemical Property of 2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetimidamide hydrochloride

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Technology Process of 2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetimidamide hydrochloride

There total 5 articles about 2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetimidamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1417917-74-8
2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetonitrile

: 1417917-75-9
2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetimidamide hydrochloride

Guidance literature:: 2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetonitrile; With sodium methylate; In methanol; at 20 ℃; for 2h;

With ammonium chloride; In methanol; at 20 ℃; for 60h;

Reference yield:

: 76362-12-4
4-(4-methoxybenzoyl)-piperidine

: 1417917-75-9
2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetimidamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / 18 h / 85 °C

2.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 70 °C

3.1: sodium methylate / methanol / 2 h / 20 °C

3.2: 60 h / 20 °C

With sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1417917-67-9
3-[4-(4-methoxybenzoyl)piperidin-1-yl]pyrrolidin-2-one

: 1417917-75-9
2-(3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopyrrolidin-1-yl)acetimidamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 0.5 h / 70 °C

2.1: sodium methylate / methanol / 2 h / 20 °C

2.2: 60 h / 20 °C

With sodium methylate; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;