2,3-dichloro-6-(2,6-dimethyl-4-ethynylphenyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

Base Information

Chemical Name:2,3-dichloro-6-(2,6-dimethyl-4-ethynylphenyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione
CAS No.:960496-99-5
Molecular Formula:C₁₆H₉Cl₂N₃O₂
Molecular Weight:346.172
Hs Code.:

Synonyms:2,3-dichloro-6-(2,6-dimethyl-4-ethynylphenyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

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Chemical Property of 2,3-dichloro-6-(2,6-dimethyl-4-ethynylphenyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

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Technology Process of 2,3-dichloro-6-(2,6-dimethyl-4-ethynylphenyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

There total 4 articles about 2,3-dichloro-6-(2,6-dimethyl-4-ethynylphenyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5,6-dichloro-3-(4-ethynyl-2,6-dimethyl-phenylcarbamoyl)-pyrazine-2-carboxylic acid

: 960496-99-5
2,3-dichloro-6-(2,6-dimethyl-4-ethynylphenyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

Guidance literature:: With oxalyl dichloride; In tetrahydrofuran; pyridine; at 50 ℃; for 16h;
DOI:10.1246/bcsj.79.1926

Reference yield:

: 4102-53-8
4-iodo-2,6-dimethylaniline

: 960496-99-5
2,3-dichloro-6-(2,6-dimethyl-4-ethynylphenyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / piperidine / Pd(PPh₃)4; CuI / various solvent(s) / 16 h / 20 °C

2: 89 percent / aq. NaOH / tetrahydrofuran; methanol / 3 h

3: tetrahydrofuran / 0.5 h / 40 °C

4: 812 g / (COCl)2 / tetrahydrofuran; pyridine / 16 h / 50 °C

With piperidine; sodium hydroxide; oxalyl dichloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; methanol; 1: Sonogashira cross-coupling reaction;
DOI:10.1246/bcsj.79.1926

Reference yield:

: 926895-24-1
2,6-dimethyl-4-[(trimethylsilyl)ethynyl]aniline

: 960496-99-5
2,3-dichloro-6-(2,6-dimethyl-4-ethynylphenyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / aq. NaOH / tetrahydrofuran; methanol / 3 h

2: tetrahydrofuran / 0.5 h / 40 °C

3: 812 g / (COCl)2 / tetrahydrofuran; pyridine / 16 h / 50 °C

With sodium hydroxide; oxalyl dichloride; In tetrahydrofuran; pyridine; methanol;
DOI:10.1246/bcsj.79.1926