4-(3-amino-4-(4-methylpiperazin-1-yl)phenyl)phthalazin-1(2H)-one

Base Information

• Chemical Name: 4-(3-amino-4-(4-methylpiperazin-1-yl)phenyl)phthalazin-1(2H)-one
• CAS No.: 1147012-96-1
• Molecular Formula: C₁₉H₂₁N₅O
• Molecular Weight: 335.409
• Mol file: 1147012-96-1.mol

Synonyms:4-(3-amino-4-(4-methylpiperazin-1-yl)phenyl)phthalazin-1(2H)-one

Chemical Property of 4-(3-amino-4-(4-methylpiperazin-1-yl)phenyl)phthalazin-1(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-amino-4-(4-methylpiperazin-1-yl)phenyl)phthalazin-1(2H)-one

There total 4 articles about 4-(3-amino-4-(4-methylpiperazin-1-yl)phenyl)phthalazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[3-amino-4-(4-methyl-piperazin-1-yl)-benzoyl]-benzoic acid methyl ester (1147012-98-3) → 4-(3-amino-4-(4-methylpiperazin-1-yl)phenyl)phthalazin-1(2H)-one (1147012-96-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 8h; Reflux;

Reference yield:

methyl 2-(4-chloro-3-nitrobenzoyl)benzoate (20643-68-9) → 4-(3-amino-4-(4-methylpiperazin-1-yl)phenyl)phthalazin-1(2H)-one (1147012-96-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 48 h / Reflux

2: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 4 h / 20 °C / 2585.81 Torr

3: hydrazine hydrate / ethanol / 8 h / Reflux

With hydrogen; hydrazine hydrate; 5% Pd(II)/C(eggshell); In methanol; ethanol; acetonitrile;

Reference yield:

2-(4'-chloro-3'-nitrobenzoyl)benzoic acid (85-54-1) → 4-(3-amino-4-(4-methylpiperazin-1-yl)phenyl)phthalazin-1(2H)-one (1147012-96-1)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 20 °C / Reflux

2: acetonitrile / 48 h / Reflux

3: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 4 h / 20 °C / 2585.81 Torr

4: hydrazine hydrate / ethanol / 8 h / Reflux

With thionyl chloride; hydrogen; hydrazine hydrate; 5% Pd(II)/C(eggshell); In methanol; ethanol; acetonitrile;

upstream raw materials:

2-(4'-chloro-3'-nitrobenzoyl)benzoic acid

methyl 2-(4-chloro-3-nitrobenzoyl)benzoate

2-[4-(4-methyl-piperazin-1-yl)-3-nitro-benzoyl]-benzoic acid methyl ester

2-[3-amino-4-(4-methyl-piperazin-1-yl)-benzoyl]-benzoic acid methyl ester

Downstream raw materials:

1-methyl-3-(2-(4-methylpiperazin-1-yl)-5-(4-oxo-3,4-dihydrophthalazin-1-yl)phenyl)urea

N-(2-(4-methylpiperazin-1-yl)-5-(4-oxo-3,4-dihydrophthalazin-1-yl)phenyl)acetamide