(-)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-5-p-tolylthiophene-2-sulfonamide

Base Information

Chemical Name:(-)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-5-p-tolylthiophene-2-sulfonamide
CAS No.:1020105-29-6
Molecular Formula:C₁₇H₁₈N₂O₄S₂
Molecular Weight:378.473
Hs Code.:

Synonyms:(-)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-5-p-tolylthiophene-2-sulfonamide

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Chemical Property of (-)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-5-p-tolylthiophene-2-sulfonamide

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Technology Process of (-)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-5-p-tolylthiophene-2-sulfonamide

There total 6 articles about (-)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-5-p-tolylthiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1345691-78-2
C₂₄H₂₄N₂O₄S₂

: 1020105-29-6
(-)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-5-p-tolylthiophene-2-sulfonamide

Guidance literature:: With methanesulfonic acid; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2011.08.068

Reference yield:

: 1020104-29-3
(+)-[1-(allyl-benzyloxy-carbamoyl)-but-3-(R)-enyl]-carbamic acid tert-butyl ester

: 1020105-29-6
(-)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-5-p-tolylthiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 8 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: pyridine / dichloromethane / 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran / 1 h / 150 °C / Microwave irradiation

5: methanesulfonic acid / 18 h / 20 °C

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.08.068

Reference yield:

: 1020104-31-7
(-)-(1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-R-yl)-carbamic acid tert-butyl ester

: 1020105-29-6
(-)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-5-p-tolylthiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: pyridine / dichloromethane / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran / 1 h / 150 °C / Microwave irradiation

4: methanesulfonic acid / 18 h / 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.08.068