(+/-)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbamidoxime

Base Information

• Chemical Name: (+/-)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbamidoxime
• CAS No.: 923272-55-3
• Molecular Formula: C₁₈H₁₇N₅O₅
• Molecular Weight: 383.363
• Mol file: 923272-55-3.mol

Synonyms:(+/-)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbamidoxime

Chemical Property of (+/-)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbamidoxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbamidoxime

There total 2 articles about (+/-)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbamidoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+/-)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbonitrile (732276-97-0) → (+/-)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbamidoxime (923272-55-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In 2-methoxy-ethanol; for 0.5h;

Reference yield:

1-(4-Nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine (143692-49-3,161832-62-8,161832-63-9) → (+/-)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbamidoxime (923272-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium chloride / DMF (N,N-dimethyl-formamide) / 20 h / 20 °C

2: hydroxylamine hydrochloride; sodium acetate / 2-methoxy-ethanol / 0.5 h

With potassium chloride; hydroxylamine hydrochloride; sodium acetate; In DMF (N,N-dimethyl-formamide); 2-methoxy-ethanol;

Reference yield: 75.0%

(+/-)-8-methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbamidoxime (923272-55-3) + orthoformic acid triethyl ester (122-51-0) → (+/-)-8-methyl-5-(4-nitrophenyl)-7-(1,2,4-oxadiazol-3-yl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

Guidance literature:

hydrogenchloride; In water; at 110 ℃; for 0.5h;

upstream raw materials:

(+/-)-8-Methyl-5-(4-nitrophenyl)-8,9-dihydro-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carbonitrile

1-(4-Nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine