3-cyclohexyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-cyclohexyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylpropanoic acid
CAS No.:1025762-88-2
Molecular Formula:C₂₄H₂₇FN₂O₂
Molecular Weight:394.489
Hs Code.:

Synonyms:3-cyclohexyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylpropanoic acid

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Chemical Property of 3-cyclohexyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylpropanoic acid

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Technology Process of 3-cyclohexyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylpropanoic acid

There total 4 articles about 3-cyclohexyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025762-85-9
methyl 3-cyclohexyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylpropanoate

: 1025762-88-2
3-cyclohexyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylpropanoic acid

Guidance literature:: With methanol; sodium hydroxide; water; In dimethyl sulfoxide; at 100 ℃;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: C₁₈H₂₄N₂O₂

: 1025762-88-2
3-cyclohexyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylpropanoic acid

Guidance literature:: With potassium phosphate; copper(l) iodide; In 1,4-dioxane; at 110 ℃; for 24h;
DOI:10.1016/j.bmcl.2013.06.089

Reference yield:

: 1456540-31-0
C₁₄H₁₈N₂O

: 1025762-88-2
3-cyclohexyl-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: titanium tetrachloride / dichloromethane / 12 h / 0 °C

2: sodium hydroxide / methanol; dimethyl sulfoxide / 12 h / 100 °C

3: copper(l) iodide; potassium phosphate / 1,4-dioxane / 24 h / 110 °C

With potassium phosphate; copper(l) iodide; titanium tetrachloride; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; 1: |Mukaiyama Aldol Addition / 3: |Buchwald-Hartwig Coupling;
DOI:10.1016/j.bmcl.2013.06.089