(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-phenylpropanamide

Base Information

Chemical Name:(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-phenylpropanamide
CAS No.:1401624-38-1
Molecular Formula:C₃₀H₃₃N₅O₃S
Molecular Weight:543.69
Hs Code.:

Synonyms:(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-phenylpropanamide

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Chemical Property of (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-phenylpropanamide

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Technology Process of (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-phenylpropanamide

There total 6 articles about (S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1401625-12-4
tert-butyl (S)-1-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

: 1401624-38-1
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-phenylpropanamide

Guidance literature:: tert-butyl (S)-1-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropylamino)-1-oxo-3-phenylpropan-2-ylcarbamate; With formic acid; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 122225-33-6
(2R)-3-tert-Butyloxycarbonyl-2-phenylmethylpropionic Acid

: 1401624-38-1
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: DMT-MM / dichloromethane / 2 h / 0 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 4

2.3: pH 8

3.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

4.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

5.1: formic acid / 4 h / 20 °C

With formic acid; 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; DMT-MM; water; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1401625-08-8
C₃₅H₄₂N₄O₇S

: 1401624-38-1
(S)-2-amino-N-((1R,2R)-1-cyano-2-(4'-(4-methylpiperazin-1-ylsulfonyl)biphenyl-4-yl)cyclopropyl)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 4 h / 20 °C

3.1: formic acid / 4 h / 20 °C

With formic acid; 1,3,5-trichloro-2,4,6-triazine; chloroformic acid ethyl ester; triethylamine; In dichloromethane; N,N-dimethyl-formamide;