Technology Process of (S)-4-(1-(5-chloro-2-(1H-tetrazol-1-yl)phenethylamino)-1-oxo-3-phenylpropan-2-ylcarbamoyl)benzoic acid
There total 11 articles about (S)-4-(1-(5-chloro-2-(1H-tetrazol-1-yl)phenethylamino)-1-oxo-3-phenylpropan-2-ylcarbamoyl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C27H25ClN6O4;
With
sodium hydroxide; water;
In
tetrahydrofuran;
at 20 ℃;
for 3.5h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 0 ℃;
pH=6;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium hydroxide; water / methanol / 20 °C
2: hydrogen; platinum(IV) oxide / methanol
3: triethylamine / tetrahydrofuran / -78 °C
4: ammonia / methanol
5: bis-[(trifluoroacetoxy)iodo]benzene; pyridine / acetonitrile; water
6: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide
7: hydrogenchloride / 1,4-dioxane
8: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide
With
pyridine; hydrogenchloride; platinum(IV) oxide; ammonia; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; bis-[(trifluoroacetoxy)iodo]benzene; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;
5: |Hofmann Rearrangement;
DOI:10.1016/j.bmcl.2015.11.089
- Guidance literature:
-
Multi-step reaction with 9 steps
1: triethylamine; palladium diacetate / acetonitrile / 24 h / 85 °C
2: sodium hydroxide; water / methanol / 20 °C
3: hydrogen; platinum(IV) oxide / methanol
4: triethylamine / tetrahydrofuran / -78 °C
5: ammonia / methanol
6: bis-[(trifluoroacetoxy)iodo]benzene; pyridine / acetonitrile; water
7: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide
8: hydrogenchloride / 1,4-dioxane
9: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide
With
pyridine; hydrogenchloride; platinum(IV) oxide; ammonia; water; hydrogen; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; bis-[(trifluoroacetoxy)iodo]benzene; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;
1: |Heck Reaction / 6: |Hofmann Rearrangement;
DOI:10.1016/j.bmcl.2015.11.089
