N⁶-benzoyl-9-{3'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine

Base Information

• Chemical Name: N⁶-benzoyl-9-{3'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine
• CAS No.: 221170-43-0
• Molecular Formula: C₄₅H₃₉N₅O₈
• Molecular Weight: 777.833

Synonyms:N⁶-benzoyl-9-{3'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine

Chemical Property of N⁶-benzoyl-9-{3'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine

Chemical Property:

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Technology Process of N⁶-benzoyl-9-{3'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine

There total 10 articles about N⁶-benzoyl-9-{3'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N6,N6-dibenzoyl-9-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine (245074-34-4) → N6-benzoyl-9-{3'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine (221170-43-0)

Guidance literature:

With dmap; 4-nitro-phenol; triethylamine; In pyridine; propan-1-ol; at 60 ℃; for 48h;

DOI:10.1002/hlca.200390349

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → N6-benzoyl-9-{3'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine (221170-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 4A MS; EtN(i-Pr)2 / CH₂Cl₂ / 1.5 h / 20 °C

2: 67 percent / 4-nitrophenol; DMAP; Et₃N / pyridine; propan-1-ol / 48 h / 60 °C

With dmap; 4-nitro-phenol; triethylamine; N-ethyl-N,N-diisopropylamine; In pyridine; propan-1-ol; dichloromethane;

DOI:10.1002/hlca.200390349

Reference yield:

N6,N6-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)adenine (245074-29-7) → N6-benzoyl-9-{3'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine (221170-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 4A MS; EtN(i-Pr)2 / CH₂Cl₂ / 1.5 h / 20 °C

2: 67 percent / 4-nitrophenol; DMAP; Et₃N / pyridine; propan-1-ol / 48 h / 60 °C

With dmap; 4-nitro-phenol; triethylamine; N-ethyl-N,N-diisopropylamine; In pyridine; propan-1-ol; dichloromethane;

DOI:10.1002/hlca.200390349

upstream raw materials:

N⁶,N⁶-dibenzoyl-9-{2'-O-benzoyl-4'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-β-D-ribopyranosyl}adenine

4,4'-dimethoxytrityl chloride

N⁶,N⁶-dibenzoyl-9-(2'-O-benzoyl-β-D-ribopyranosyl)adenine

benzoyl chloride

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