N-benzyloxycarbonyl-γ-butyrylhydrazid

Base Information

Chemical Name:N-benzyloxycarbonyl-γ-butyrylhydrazid
CAS No.:120569-71-3
Molecular Formula:C₁₂H₁₇N₃O₃
Molecular Weight:251.285
Hs Code.:

Synonyms:N-benzyloxycarbonyl-γ-butyrylhydrazid

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Chemical Property of N-benzyloxycarbonyl-γ-butyrylhydrazid

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Technology Process of N-benzyloxycarbonyl-γ-butyrylhydrazid

There total 2 articles about N-benzyloxycarbonyl-γ-butyrylhydrazid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: tert-butyl 2-(4-(((benzyloxy)carbonyl)amino)butanoyl)hydrazine-1-carboxylate

: 120569-71-3
N-benzyloxycarbonyl-γ-butyrylhydrazid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3.5h; Inert atmosphere;
DOI:10.1016/j.bioorg.2018.08.016

Reference yield:

: 5105-78-2
4-(benzyloxycarbonylamino)butyric acid

: 120569-71-3
N-benzyloxycarbonyl-γ-butyrylhydrazid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;
DOI:10.1021/acs.jmedchem.5b01464

Reference yield: 85.2%

: 72086-72-7
N-tert-butoxycarbonylglutamic acid methyl ester

: 120569-71-3
N-benzyloxycarbonyl-γ-butyrylhydrazid

: methyl N⁵-(4-(((benzyloxy)carbonyl)amino)butanamido)-N²-(tert-butoxycarbonyl)-L-glutaminate

Guidance literature:: N-tert-butoxycarbonylglutamic acid methyl ester; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-benzyloxycarbonyl-γ-butyrylhydrazid; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 16h;
DOI:10.1021/acs.jmedchem.5b01464