6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide

Base Information

• Chemical Name: 6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide
• CAS No.: 1037758-74-9
• Molecular Formula: C₂₄H₁₉F₂N₃O₅S
• Molecular Weight: 499.495
• Mol file: 1037758-74-9.mol

Synonyms:6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide

Chemical Property of 6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide

There total 12 articles about 6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

C25H20F2N2O6S → 6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide (1037758-74-9)

Guidance literature:

With hydrogenchloride; methanol; In 1,4-dioxane; at 90 ℃; for 3h;

Reference yield: 65.0%

6-(2,5-difluorobenzyl)-8-(2-methoxypyridin-3-yl)-N-(methylsulfonyl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide (1037763-79-3) → 6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide (1037758-74-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 90 ℃; for 3h; Sealed tube;

DOI:10.1021/ol203177g

Reference yield:

methyl 8-(2-methoxypyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxylate (1037763-72-6) → 6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxamide (1037758-74-9)

Guidance literature:

Multi-step reaction with 5 steps

1: tetra-(n-butyl)ammonium iodide; caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

2: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 5 h / 50 °C

3: tetrahydrofuran / 2 h / 70 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 48 h / 35 °C

5: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 90 °C / Sealed tube

With hydrogenchloride; lithium hydroxide monohydrate; tetra-(n-butyl)ammonium iodide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/ol203177g

upstream raw materials:

methyl 3,6-dihydro-2H-furo[2,3-e]indole-7-carboxylate

methyl 8-iodo-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxylate

methyl 8-(2-methoxypyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxylate

methyl 6-(2,5-difluorobenzyl)-8-(2-methoxypyridin-3-yl)-3,6-dihydro-2H-furo[2,3-e]indole-7-carboxylate