N-(3-{2-chloro-5-[4-({2-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-methoxy-1,3,5-triazin-2-yl]phenoxy}propyl)methanesulfonamide

Base Information

Chemical Name:N-(3-{2-chloro-5-[4-({2-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-methoxy-1,3,5-triazin-2-yl]phenoxy}propyl)methanesulfonamide
CAS No.:1443151-75-4
Molecular Formula:C₂₃H₂₆ClF₂N₅O₅S
Molecular Weight:558.006
Hs Code.:

Synonyms:N-(3-{2-chloro-5-[4-({2-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-methoxy-1,3,5-triazin-2-yl]phenoxy}propyl)methanesulfonamide

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Chemical Property of N-(3-{2-chloro-5-[4-({2-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-methoxy-1,3,5-triazin-2-yl]phenoxy}propyl)methanesulfonamide

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Technology Process of N-(3-{2-chloro-5-[4-({2-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-methoxy-1,3,5-triazin-2-yl]phenoxy}propyl)methanesulfonamide

There total 6 articles about N-(3-{2-chloro-5-[4-({2-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-methoxy-1,3,5-triazin-2-yl]phenoxy}propyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443151-86-7
N-{3-[2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propyl}methanesulfonamide

: 1443151-81-2
4-chloro-N-{2-[4-(difluoromethoxy)phenyl]ethyl}-6-methoxy-1,3,5-triazin-2-amine

: 1443151-75-4
N-(3-{2-chloro-5-[4-({2-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-methoxy-1,3,5-triazin-2-yl]phenoxy}propyl)methanesulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; water; for 2.5h; Reflux;

Reference yield:

: 183802-98-4
5-bromo-2-chlorophenol

: 1443151-75-4
N-(3-{2-chloro-5-[4-({2-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-methoxy-1,3,5-triazin-2-yl]phenoxy}propyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 20 °C

2.1: hydrazine hydrate / ethanol / 4 h / Reflux

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2.5 h / Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,2-dimethoxyethane / 2.5 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium hydride; caesium carbonate; hydrazine hydrate; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1443151-87-8
2-[3-(5-bromo-2-chlorophenoxy)propyl]-1H-isoindole-1,3(2H)-dione

: 1443151-75-4
N-(3-{2-chloro-5-[4-({2-[4-(difluoromethoxy)phenyl]ethyl}amino)-6-methoxy-1,3,5-triazin-2-yl]phenoxy}propyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 4 h / Reflux

2: triethylamine / dichloromethane / 1 h / 20 °C

3: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2.5 h / Reflux

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / water; 1,2-dimethoxyethane / 2.5 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; caesium carbonate; hydrazine hydrate; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;