(2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanal

Base Information

Chemical Name:(2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanal
CAS No.:400737-49-7
Molecular Formula:C₂₈H₅₂O₆Si₂
Molecular Weight:540.888
Hs Code.:

Synonyms:(2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanal

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Chemical Property of (2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanal

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Technology Process of (2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanal

There total 10 articles about (2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 400737-46-4
(2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanoic acid methoxy-methyl-amide

: 400737-49-7
(2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanal

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 2h;
DOI:10.1002/1521-3773(20011015)40:20<3849::AID-ANIE3849>3.0.CO;2-M

Reference yield:

: 400737-43-1
(2R,3S,4R,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-octanoic acid methoxy-methyl-amide

: 400737-49-7
(2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanal

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-lutidine / CH₂Cl₂ / 1 h / -30 °C

2: 5.0 g / DIBAL-H / CH₂Cl₂; toluene / 2 h / -78 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; In dichloromethane; toluene;
DOI:10.1021/ja0304953

Reference yield:

: (R)-4-Benzyl-3-[(4R,5R,7R)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-octanoyl]-oxazolidin-2-one

: 400737-49-7
(2R,3S,4S,5R,7R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-methoxy-7-(4-methoxy-benzyloxy)-2,4-dimethyl-3-trimethylsilanyloxy-octanal

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / AlMe₃ / CH₂Cl₂ / 12 h / 25 °C

2: 2,6-lutidine / CH₂Cl₂ / 1 h / -30 °C

3: 5.0 g / DIBAL-H / CH₂Cl₂; toluene / 2 h / -78 °C

With 2,6-dimethylpyridine; trimethylaluminum; diisobutylaluminium hydride; In dichloromethane; toluene;
DOI:10.1021/ja0304953