methyl 6-((4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinate

Base Information

Chemical Name:methyl 6-((4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinate
CAS No.:1374672-12-4
Molecular Formula:C₁₇H₁₅FN₄O₃
Molecular Weight:342.33
Hs Code.:

Synonyms:methyl 6-((4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 6-((4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinate

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Technology Process of methyl 6-((4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinate

There total 3 articles about methyl 6-((4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 73781-91-6
6-Chloronicotinic acid methyl ester

: 1374672-86-2
(4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazole-5-yl) methanol

: 1374672-12-4
methyl 6-((4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinate

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 16.5h;

Reference yield:

: 1374672-84-0
4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazole

: 1374672-12-4
methyl 6-((4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinate

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -75 - 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0.5 h / 20 °C / Inert atmosphere

3: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 0 - 20 °C

With sodium tetrahydroborate; n-butyllithium; sodium hydride; In tetrahydrofuran; methanol; hexane; mineral oil;

Reference yield:

: 1374672-85-1
4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazole-5-carbaldehyde

: 1374672-12-4
methyl 6-((4-(2-fluorophenyl)-1-methyl-1H-1,2,3-triazol-5-yl)methoxy)nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0.5 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 0 - 20 °C

With sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol; mineral oil;