(E)-(3S,10R,16S)-3-Isopropyl-10-(4-methoxy-benzyl)-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Base Information

Chemical Name:(E)-(3S,10R,16S)-3-Isopropyl-10-(4-methoxy-benzyl)-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone
CAS No.:711028-25-0
Molecular Formula:C₃₃H₄₀N₂O₇
Molecular Weight:576.69
Hs Code.:

Synonyms:(E)-(3S,10R,16S)-3-Isopropyl-10-(4-methoxy-benzyl)-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

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Chemical Property of (E)-(3S,10R,16S)-3-Isopropyl-10-(4-methoxy-benzyl)-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

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Technology Process of (E)-(3S,10R,16S)-3-Isopropyl-10-(4-methoxy-benzyl)-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

There total 6 articles about (E)-(3S,10R,16S)-3-Isopropyl-10-(4-methoxy-benzyl)-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-(3-Amino-propionyloxy)-3-methyl-butyric acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester

: 711028-25-0
(E)-(3S,10R,16S)-3-Isopropyl-10-(4-methoxy-benzyl)-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: (S)-2-(3-Amino-propionyloxy)-3-methyl-butyric acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester; With hydrogenchloride; In diethyl ether;

With diphenylphosphorus azide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1016/j.bmcl.2004.02.080

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 711028-25-0
(E)-(3S,10R,16S)-3-Isopropyl-10-(4-methoxy-benzyl)-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. NaHCO₃; TBAI / CH₂Cl₂

2.1: 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂

3.1: H₂ / Pd/C / methanol

4.1: 100 percent / 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂

5.1: TFA / CH₂Cl₂ / 0 °C

6.1: HCl / diethyl ether

6.2: diphenylphosphorus azide; NaHCO₃ / dimethylformamide / 0 °C

With hydrogenchloride; dmap; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2004.02.080

Reference yield:

: 65138-05-8
(S)-2-hydroxy-3-methylbutyric acid benzyl ester

: 711028-25-0
(E)-(3S,10R,16S)-3-Isopropyl-10-(4-methoxy-benzyl)-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂

2.1: H₂ / Pd/C / methanol

3.1: 100 percent / 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂

4.1: TFA / CH₂Cl₂ / 0 °C

5.1: HCl / diethyl ether

5.2: diphenylphosphorus azide; NaHCO₃ / dimethylformamide / 0 °C

With hydrogenchloride; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2004.02.080