benzyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate

Base Information

Chemical Name:benzyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate
CAS No.:1352089-48-5
Molecular Formula:C₃₁H₃₄N₂O₆
Molecular Weight:530.621
Hs Code.:

Synonyms:benzyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate

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Chemical Property of benzyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate

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Technology Process of benzyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate

There total 1 articles about benzyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzyl N-(2-aminoethyl)glycinate ditosylate

: 1352089-48-5
benzyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 5.33 h / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/hlca.201100243

Reference yield: 86.0%

: 1352089-48-5
benzyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate

: 76-05-1
trifluoroacetic acid

: 1421940-85-3
H-Aeg(Fmoc)-OBn*TFA

Guidance literature:: With triethylsilane; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1002/hlca.201100243

Reference yield:

: 1352089-48-5
benzyl N-[(9-H-fluoren-9-yl)methoxycarbonyl]-N-(2-tert-butoxycarbonylaminoethyl)glycinate

: 1352089-50-9
benzyl N-{2-[N-(2-tert-butoxycarbonylaminoethyl)-N-(prop-2-en-1-yloxycarbonyl)]glycylaminoethyl}-N-[(9H-fluoren-9-yl)methyloxycarbonyl]glycinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylsilane / dichloromethane / 3 h / 0 - 20 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With triethylsilane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100243