2-cyclopropyl-1-(difluoromethoxy)-4-((4-fluoro-3-(3-fluoropropoxy)phenyl)ethynyl)benzene

Base Information

Chemical Name:2-cyclopropyl-1-(difluoromethoxy)-4-((4-fluoro-3-(3-fluoropropoxy)phenyl)ethynyl)benzene
CAS No.:1062614-22-5
Molecular Formula:C₂₁H₁₈F₄O₂
Molecular Weight:378.366
Hs Code.:

Synonyms:2-cyclopropyl-1-(difluoromethoxy)-4-((4-fluoro-3-(3-fluoropropoxy)phenyl)ethynyl)benzene

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Chemical Property of 2-cyclopropyl-1-(difluoromethoxy)-4-((4-fluoro-3-(3-fluoropropoxy)phenyl)ethynyl)benzene

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Technology Process of 2-cyclopropyl-1-(difluoromethoxy)-4-((4-fluoro-3-(3-fluoropropoxy)phenyl)ethynyl)benzene

There total 6 articles about 2-cyclopropyl-1-(difluoromethoxy)-4-((4-fluoro-3-(3-fluoropropoxy)phenyl)ethynyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1062615-18-2
4-bromo-1-fluoro-2-(3-fluoropropoxy)benzene

: 1062615-44-4
2-cyclopropyl-1-difluoromethoxy-4-ethynyl-benzene

: 1062614-22-5
2-cyclopropyl-1-(difluoromethoxy)-4-((4-fluoro-3-(3-fluoropropoxy)phenyl)ethynyl)benzene

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: 1062615-36-4
2-bromo-1-difluoromethoxy-4-iodo-benzene

: 1062614-22-5
2-cyclopropyl-1-(difluoromethoxy)-4-((4-fluoro-3-(3-fluoropropoxy)phenyl)ethynyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 0 °C

2: potassium phosphate / palladium diacetate; tricyclohexylphosphine / water; toluene / 6 h / 100 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

4: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 50 °C

With potassium phosphate; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: (3-bromo-4-difluoromethoxy-phenylethynyl)triisopropyl-silane

: 1062614-22-5
2-cyclopropyl-1-(difluoromethoxy)-4-((4-fluoro-3-(3-fluoropropoxy)phenyl)ethynyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / palladium diacetate; tricyclohexylphosphine / water; toluene / 6 h / 100 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

3: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 50 °C

With potassium phosphate; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;