N-<2-(S)-<(tert-butoxycarbonyl)amino>-3-phenylpropyl>-methionine methyl ester

Base Information

Chemical Name:N-<2-(S)-<(tert-butoxycarbonyl)amino>-3-phenylpropyl>-methionine methyl ester
CAS No.:158861-43-9
Molecular Formula:C₂₀H₃₂N₂O₄S
Molecular Weight:396.551
Hs Code.:

Synonyms:N-<2-(S)-<(tert-butoxycarbonyl)amino>-3-phenylpropyl>-methionine methyl ester

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Chemical Property of N-<2-(S)-<(tert-butoxycarbonyl)amino>-3-phenylpropyl>-methionine methyl ester

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Technology Process of N-<2-(S)-<(tert-butoxycarbonyl)amino>-3-phenylpropyl>-methionine methyl ester

There total 1 articles about N-<2-(S)-<(tert-butoxycarbonyl)amino>-3-phenylpropyl>-methionine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 72155-45-4
Boc-L-phenylalaninal

: 2491-18-1
(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride

: 158861-43-9
N-<2-(S)-<(tert-butoxycarbonyl)amino>-3-phenylpropyl>-methionine methyl ester

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; for 2h;
DOI:10.1021/jm00032a004

Reference yield: 100.0%

: 158861-43-9
N-<2-(S)-<(tert-butoxycarbonyl)amino>-3-phenylpropyl>-methionine methyl ester

: 158861-44-0
N-(2-(S)-amino-3-phenylpropyl)methionine methyl ester

Guidance literature:: With hydrogenchloride; In ethyl acetate; at -20 ℃; for 0.5h;
DOI:10.1021/jm00032a004

Reference yield:

: 158861-43-9
N-<2-(S)-<(tert-butoxycarbonyl)amino>-3-phenylpropyl>-methionine methyl ester

: (S)-2-{(S)-2-[(S)-2-((R)-2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propylamino)-3-methyl-pentanoylamino]-3-phenyl-propylamino}-4-methylsulfanyl-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / HCl (g) / ethyl acetate / 0.5 h / -20 °C

2: 0.33 g / 1-hydroxybenzotriazole, EDC, N-methylmorpholine / dimethylformamide / 20 h / Ambient temperature

3: 85 percent / LiOH / methanol; H₂O / 31 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00032a004