cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole

Base Information

Chemical Name:cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole
CAS No.:147201-38-5
Molecular Formula:C₂₀H₂₂BrNO
Molecular Weight:372.305
Hs Code.:

Synonyms:cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole

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Chemical Property of cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole

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Technology Process of cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole

There total 4 articles about cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 147145-09-3
(4bS,7R,9aS)-4-Bromo-7-phenyl-4b,5,7,8,10,11-hexahydro-9-oxa-6a-aza-pentaleno[1,6a-a]naphthalen-6-one

: 147201-38-5
cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole

Guidance literature:: With borane-THF; In tetrahydrofuran; at -78 ℃; for 7h; Heating;
DOI:10.1021/jo960185l

Reference yield: 15.0%

: 147145-09-3
(4bS,7R,9aS)-4-Bromo-7-phenyl-4b,5,7,8,10,11-hexahydro-9-oxa-6a-aza-pentaleno[1,6a-a]naphthalen-6-one

: trans-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole

: 147201-38-5
cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo960185l

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 147201-38-5
cis-(-)-2,3,3a,4,5,9b-hexahydro-9-bromo-3-(2(R)-1-hydroxypheneth-2-yl)-1H-benz[e]indole

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / toluene / 19 h / Heating

2: 62 percent / lithium aluminum hydride / tetrahydrofuran / -78 - 20 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; toluene; 1: Condensation / 2: Reduction;
DOI:10.1021/jo960185l