N²-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine

Base Information

Chemical Name:N²-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine
CAS No.:146954-68-9
Molecular Formula:C₂₄H₃₅N₅O₈
Molecular Weight:521.571
Hs Code.:

N<sup>2</sup>-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine

Synonyms:N²-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine

Suppliers and Price of N²-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N²-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N²-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine

There total 1 articles about N²-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38819-10-2
9-β-D-arabinofuranosylguanine

: 146954-68-9
N²-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) TMSCl, pyridine, 3.) NH₄OH

2: TsOH / dioxane

With pyridine; ammonium hydroxide; chloro-trimethyl-silane; toluene-4-sulfonic acid; In 1,4-dioxane;
DOI:10.1080/07328319708006246

Reference yield:

: 146954-68-9
N²-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine

: 78842-13-4
2'-deoxy-2'-fluoroguanosine

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP / CH₂Cl₂

2: TBAF / tetrahydrofuran

3: Dowex-50 / methanol

4: NH₄OH / 24 h / 55 °C

With dmap; ammonium hydroxide; Dowex-50; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1080/07328319708006246

Reference yield:

: 146954-68-9
N²-isobutyryl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)guanine

: 144089-96-3
N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine, (N,N-dimethylamino)pyrydine / CH₂Cl₂ / 1 h / 5 °C

2: tertbutylammonium fluoride / tetrahydrofuran / 5 h / 5 °C

3: 41 percent / Dowex 50W x 2-100 / methanol / 1 h / 23 °C

4: 87 percent / pyridine, Et₃N / 4 h / 23 °C

With pyridine; tert-butyl-ammonium fluoride; (N,N-dimethylamino)pyrydine; Dowex 50W x 2-100; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm00059a007