4-METHOXY-3-PYRIDINECARBOXYLIC ACID

Base Information

• Chemical Name: 4-METHOXY-3-PYRIDINECARBOXYLIC ACID
• CAS No.: 10177-31-8
• Molecular Formula: C7H7 N O3
• Molecular Weight: 153.137
• Hs Code.: 2933399090
• Mol file: 10177-31-8.mol

Synonyms:Nicotinicacid, 4-methoxy- (7CI,8CI); 4-Methoxynicotinic acid;4-Methoxypyridine-3-carboxylic acid

Chemical Property of 4-METHOXY-3-PYRIDINECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 178-179℃
• Refractive Index: 1.55
• Boiling Point: 314.728°C at 760 mmHg
• PKA: 2.09±0.10(Predicted)
• Flash Point: 144.143°C
• PSA: 59.42000
• Density: 1.285g/cm³
• LogP: 0.78840
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxynicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-3-PYRIDINECARBOXYLIC ACID

There total 1 articles about 4-METHOXY-3-PYRIDINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-methoxy-nicotinic acid (10177-31-8)

Guidance literature:

4-Chlor-nicotinsaeure, Me.;

DOI:10.1039/j39660001816

Reference yield: 61.0%

4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-methoxypyridin-3-amine + 4-methoxy-nicotinic acid (10177-31-8) → N-(4-(4-(2,4-difluorophenoxy)piperidin-1-yl)-6-methoxypyridin-3-yl)-4-methoxynicotinamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In 1-methyl-pyrrolidin-2-one; at 50 ℃; for 25h;

Reference yield: 48.0%

2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(methylsulfonyl)aniline + 4-methoxy-nicotinic acid (10177-31-8) → N-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-5-(methylsulfonyl)phenyl)-4-methoxynicotinamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

Downstream raw materials:

5-(4-{2-[5-(4-methoxypyridin-3-yl)-1,2,4-oxadiazol-3-yl]-3-methylbutan-2-yl}phenyl)pyrimidin-2-amine