Prostaglandin F1beta

Base Information

Chemical Name:Prostaglandin F1beta
CAS No.:10164-73-5
Molecular Formula:C₂₀H₃₆O₅
Molecular Weight:356.503
Hs Code.:
Nikkaji Number:J15.594B
Metabolomics Workbench ID:2430
Mol file:10164-73-5.mol

Synonyms:PGF1beta;prostaglandin F1 beta;prostaglandin F1beta;prostaglandin F1beta, (8beta,9beta,11beta,12alpha,13E,15R)-isomer;prostaglandin F1beta, (9beta,11alpha,13E,15S)-isomer

Suppliers and Price of Prostaglandin F1beta

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
Prostaglandin F1β ≥98%
1mg
$ 51.00

Cayman Chemical
Prostaglandin F1β ≥98%
10mg
$ 408.00

Cayman Chemical
Prostaglandin F1β ≥98%
5mg
$ 230.00

AK Scientific
9beta,11alpha,15S-Trihydroxy-prost-13E-en-1-oicacid
1mg
$ 168.00

Total 7 raw suppliers

Chemical Property of Prostaglandin F1beta

Chemical Property:

Vapor Pressure:2.75E-13mmHg at 25°C
Refractive Index:1.555
Boiling Point:526.5°C at 760 mmHg
Flash Point:286.3°C
PSA：97.99000
Density:1.136g/cm³
LogP:3.26690
XLogP3:3.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:13
Exact Mass:356.25627424
Heavy Atom Count:25
Complexity:396

Purity/Quality:

98%,99%, ^*data from raw suppliers

Prostaglandin F1β ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC1C(CC(C1CCCCCCC(=O)O)O)O)O
Isomeric SMILES:CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@H]([C@@H]1CCCCCCC(=O)O)O)O)O

Technology Process of Prostaglandin F1beta

There total 39 articles about Prostaglandin F1beta which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 71120-99-5,71121-00-1,72120-47-9
2β-<(1E)-3-<(tert-butyldimethylsilyl)oxy>oct-1-enyl>-3α-(6-carboxyhexyl)-1α,4α-dihydroxycyclopentanone

: 745-62-0,3613-66-9,10164-73-5,17066-90-9,20348-60-1,21562-54-9,26771-95-9,26771-96-0,34388-84-6,34388-86-8,34388-87-9,34388-89-1,34402-61-4,34437-28-0,37785-86-7,37818-61-4,42048-97-5,42587-03-1,42607-55-6,42607-56-7,54422-22-9,54422-23-0,55528-78-4,57759-92-9,57759-93-0,61375-87-9,61557-40-2,62860-86-0,62960-89-8
(+/-)-prostaglandin F1α

Guidance literature:: With hydrogen fluoride; In water; acetonitrile; for 1h; Ambient temperature;
DOI:10.1021/jo00231a014

Reference yield:

: 78823-20-8
trans-4-<(1E)-3-<(tert-butyldimethylsilyl)oxy>oct-1-enyl>-2,3-epoxycyclopentanone

: 745-62-0,3613-66-9,10164-73-5,17066-90-9,20348-60-1,21562-54-9,26771-95-9,26771-96-0,34388-84-6,34388-86-8,34388-87-9,34388-89-1,34402-61-4,34437-28-0,37785-86-7,37818-61-4,42048-97-5,42587-03-1,42607-55-6,42607-56-7,54422-22-9,54422-23-0,55528-78-4,57759-92-9,57759-93-0,61375-87-9,61557-40-2,62860-86-0,62960-89-8
(+/-)-prostaglandin F1α

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to r.t., 6 h

2: 1.) CuCN / 1.) diethyl ether, -40 deg C, 1.5 h, 2.) ether, from -78 deg C to -10 deg C, overnight

3: KF, pH 7 phosphate buffer / ethanol / 3 h / Ambient temperature

4: 84 percent / L-selectride / tetrahydrofuran / 6 h / Ambient temperature

5: 75 percent / O₂ / PtO₂ / acetone; H₂O / 4 h / 40 °C

6: 90 percent / 47-52percent aq. HF / acetonitrile; H₂O / 1 h / Ambient temperature

With potassium fluoride; pH 7 phosphate buffer; hydrogen fluoride; oxygen; L-Selectride; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; ethanol; water; acetone; acetonitrile;
DOI:10.1021/jo00231a014

Reference yield:

: 93566-56-4,93711-56-9,110548-21-5
trans-4,5-epoxy-3-<(1E)-3-<(tert-butyldimethylsilyl)oxy>oct-1-enyl>-1-<(triethylsilyl)oxy>cyclopentene

: 745-62-0,3613-66-9,10164-73-5,17066-90-9,20348-60-1,21562-54-9,26771-95-9,26771-96-0,34388-84-6,34388-86-8,34388-87-9,34388-89-1,34402-61-4,34437-28-0,37785-86-7,37818-61-4,42048-97-5,42587-03-1,42607-55-6,42607-56-7,54422-22-9,54422-23-0,55528-78-4,57759-92-9,57759-93-0,61375-87-9,61557-40-2,62860-86-0,62960-89-8
(+/-)-prostaglandin F1α

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) CuCN / 1.) diethyl ether, -40 deg C, 1.5 h, 2.) ether, from -78 deg C to -10 deg C, overnight

2: KF, pH 7 phosphate buffer / ethanol / 3 h / Ambient temperature

3: 84 percent / L-selectride / tetrahydrofuran / 6 h / Ambient temperature

4: 75 percent / O₂ / PtO₂ / acetone; H₂O / 4 h / 40 °C

5: 90 percent / 47-52percent aq. HF / acetonitrile; H₂O / 1 h / Ambient temperature

With potassium fluoride; pH 7 phosphate buffer; hydrogen fluoride; oxygen; L-Selectride; platinum(IV) oxide; In tetrahydrofuran; ethanol; water; acetone; acetonitrile;
DOI:10.1021/jo00231a014