C₄₈H₅₇N₃O₁₉

Base Information

• Chemical Name: C₄₈H₅₇N₃O₁₉
• CAS No.: 849222-12-4
• Molecular Formula: C₄₈H₅₇N₃O₁₉
• Molecular Weight: 979.989
• Mol file: 849222-12-4.mol

Synonyms:C₄₈H₅₇N₃O₁₉

Chemical Property of C₄₈H₅₇N₃O₁₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₅₇N₃O₁₉

There total 18 articles about C₄₈H₅₇N₃O₁₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-acetamido-4-O-acetyl-3-O-{2-acetamido-3-O-benzyl-4-O-(2-acetamido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-β-D-glucopyranosyl)-2-deoxy-β-D-mannopyranosyl}-2-deoxy-β-L-galactopyranoside (849222-11-3) → C48H57N3O19 (849222-12-4)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; tetrabutylammomium bromide; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate; In dichloromethane; for 16.5h;

DOI:10.1002/chem.200400862

Reference yield:

(2S,3S,4S,5S,6S)-5-Azido-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-3,4-diol → C48H57N3O19 (849222-12-4)

Guidance literature:

Multi-step reaction with 13 steps

1: 1.00 g / pyridine / 4 h

2: CSA / dimethylformamide / 1 h

3: 943 mg / aq. AcOH / 0.25 h

4: 53 percent / 1-benzenesulfinyl piperidine; tri-tert-butylpyrimidine; Tf₂O / 3 Angstroem molecular sieves / CH₂Cl₂ / -60 - 20 °C

5: 62 percent / CSA / tetrahydrofuran; methanol / 18 h

6: 72 percent / DMAP; pyridine / 6 h

7: 71 percent / 1-benzenesulfinyl piperidine; tri-tert-butylpyrimidine; Tf₂O / 3 Angstroem molecular sieves / CH₂Cl₂ / 2 h / -60 - -20 °C

8: ethylenediamine; 3 Angstroem molecular sieves / butan-1-ol / 12 h / 90 °C

9: 74 mg / pyridine / 3 h

10: Me₃P; H₂O / tetrahydrofuran / 72 h

11: 31 mg / pyridine / 16 h

12: 75 percent / HF*pyridine; pyridine / tetrahydrofuran

13: KBr; n-Bu₄NBr; TEMPO / aq. NaHCO₃; NaOCl / CH₂Cl₂ / 16.5 h

With pyridine; dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; 1-benzenesulfinyl piperidine; trifluoromethylsulfonic anhydride; 2,4,5-tri-tert-butylpyrimidine; 3 A molecular sieve; camphor-10-sulfonic acid; tetrabutylammomium bromide; water; pyridine hydrogenfluoride; acetic acid; ethylenediamine; potassium bromide; trimethylphosphane; sodium hypochlorite; 3 A molecular sieve; sodium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1002/chem.200400862

Reference yield:

methyl 3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-L-galactopyranoside (849222-01-1) → C48H57N3O19 (849222-12-4)

Guidance literature:

Multi-step reaction with 14 steps

1: t-BuOK / methanol / 1 h

2: 1.00 g / pyridine / 4 h

3: CSA / dimethylformamide / 1 h

4: 943 mg / aq. AcOH / 0.25 h

5: 53 percent / 1-benzenesulfinyl piperidine; tri-tert-butylpyrimidine; Tf₂O / 3 Angstroem molecular sieves / CH₂Cl₂ / -60 - 20 °C

6: 62 percent / CSA / tetrahydrofuran; methanol / 18 h

7: 72 percent / DMAP; pyridine / 6 h

8: 71 percent / 1-benzenesulfinyl piperidine; tri-tert-butylpyrimidine; Tf₂O / 3 Angstroem molecular sieves / CH₂Cl₂ / 2 h / -60 - -20 °C

9: ethylenediamine; 3 Angstroem molecular sieves / butan-1-ol / 12 h / 90 °C

10: 74 mg / pyridine / 3 h

11: Me₃P; H₂O / tetrahydrofuran / 72 h

12: 31 mg / pyridine / 16 h

13: 75 percent / HF*pyridine; pyridine / tetrahydrofuran

14: KBr; n-Bu₄NBr; TEMPO / aq. NaHCO₃; NaOCl / CH₂Cl₂ / 16.5 h

With pyridine; dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; 1-benzenesulfinyl piperidine; trifluoromethylsulfonic anhydride; 2,4,5-tri-tert-butylpyrimidine; 3 A molecular sieve; camphor-10-sulfonic acid; potassium tert-butylate; tetrabutylammomium bromide; water; pyridine hydrogenfluoride; acetic acid; ethylenediamine; potassium bromide; trimethylphosphane; sodium hypochlorite; 3 A molecular sieve; sodium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1002/chem.200400862

upstream raw materials:

methyl 2-acetamido-4-O-acetyl-3-O-{2-acetamido-3-O-benzyl-4-O-(2-acetamido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-β-D-glucopyranosyl)-2-deoxy-β-D-mannopyranosyl}-2-deoxy-β-L-galactopyranoside

methyl 3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-L-galactopyranoside

Acetic acid (2S,3R,4R,5S)-3,5-diacetoxy-2-acetoxymethyl-6-bromo-tetrahydro-pyran-4-yl ester

phenyl 3,4,6-tri-O-acetyl-2-azido-2-deoxy-1-seleno-α-L-galactopyranoside