4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-en-1-ol

Base Information

Chemical Name:4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-en-1-ol
CAS No.:850312-48-0
Molecular Formula:C₂₆H₃₈O₃Si
Molecular Weight:426.671
Hs Code.:

4-{2-benzyloxy-5-[1-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-en-1-ol

Synonyms:4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-en-1-ol

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Chemical Property of 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-en-1-ol

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Technology Process of 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-en-1-ol

There total 8 articles about 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 850312-57-1
acetic acid 4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-enyl ester

: 850312-48-0
4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-en-1-ol

Guidance literature:: With potassium carbonate; In methanol; water; at 20 ℃; for 2h;
DOI:10.1016/j.tetasy.2005.01.011

Reference yield:

: 1838-94-4
isoprene epoxide

: 850312-48-0
4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / Pd(PPh₃) / CH₂Cl₂ / 4 h / 20 °C

2: 98 percent / Et₃N; DMAP / ethyl acetate / 4 h / 20 °C

3: 98 percent / HCl / CH₂Cl₂ / 0.03 h / 20 °C

4: 92 percent / K₂CO₃ / acetone / 12 h / Heating

5: 90 percent / NaBH₄ / methanol / 2 h / 0 °C

6: 90 percent / imidazole; DMAP / CH₂Cl₂ / 0 - 20 °C

7: 97 percent / K₂CO₃ / methanol; H₂O / 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; potassium carbonate; triethylamine; Pd(PPh₃); In methanol; dichloromethane; water; ethyl acetate; acetone; 3: Claisen rearrangement;
DOI:10.1016/j.tetasy.2005.01.011

Reference yield:

: 99-93-4
4-Hydroxyacetophenone

: 850312-48-0
4-{2-benzyloxy-5-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-2-methyl-but-2-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / Pd(PPh₃) / CH₂Cl₂ / 4 h / 20 °C

2: 98 percent / Et₃N; DMAP / ethyl acetate / 4 h / 20 °C

3: 98 percent / HCl / CH₂Cl₂ / 0.03 h / 20 °C

4: 92 percent / K₂CO₃ / acetone / 12 h / Heating

5: 90 percent / NaBH₄ / methanol / 2 h / 0 °C

6: 90 percent / imidazole; DMAP / CH₂Cl₂ / 0 - 20 °C

7: 97 percent / K₂CO₃ / methanol; H₂O / 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; potassium carbonate; triethylamine; Pd(PPh₃); In methanol; dichloromethane; water; ethyl acetate; acetone; 3: Claisen rearrangement;
DOI:10.1016/j.tetasy.2005.01.011