Technology Process of benzyl 4,6-O-benzylidene-3-deoxy-3-C-methyl-2-oximino-α-D-arabino-hexapyranoside
There total 8 articles about benzyl 4,6-O-benzylidene-3-deoxy-3-C-methyl-2-oximino-α-D-arabino-hexapyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide; hydroxylamine hydrochloride;
In
methanol; water;
Ambient temperature;
pH=7;
DOI:10.1021/jo00299a044
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 36 percent / p-toluenesulfonic acid monohydrate / acetonitrile / 1.25 h / Ambient temperature
2: 1. NaH 2. (p-tolylsulfonyl)imidazole / 1. mineral oil, DMF, 2 h 2. 1 h
3: 2. pyridine / 1. THF, Et2O, 8 days heating 2. 18 h, room temperature
4: 92 percent / sodium methoxide / methanol / 20 h / Ambient temperature
5: 15.2 g / trifluoroacetic anhydride, methylsulfoxide / CH2Cl2 / 1.5 h / -60 °C
6: 80 percent / triethylamine / dimethylformamide / 20 h / Ambient temperature
7: 100 percent / hydroxylamine hydrochloride, NaOH / H2O; methanol / Ambient temperature; pH=7
With
pyridine; sodium hydroxide; NaH 2. (p-tolylsulfonyl)imidazole; hydroxylamine hydrochloride; sodium methylate; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00299a044
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 36 percent / p-toluenesulfonic acid monohydrate / acetonitrile / 1.25 h / Ambient temperature
2: 1. NaH 2. (p-tolylsulfonyl)imidazole / 1. mineral oil, DMF, 2 h 2. 1 h
3: 2. pyridine / 1. THF, Et2O, 8 days heating 2. 18 h, room temperature
4: 92 percent / sodium methoxide / methanol / 20 h / Ambient temperature
5: 15.2 g / trifluoroacetic anhydride, methylsulfoxide / CH2Cl2 / 1.5 h / -60 °C
6: 80 percent / triethylamine / dimethylformamide / 20 h / Ambient temperature
7: 100 percent / hydroxylamine hydrochloride, NaOH / H2O; methanol / Ambient temperature; pH=7
With
pyridine; sodium hydroxide; NaH 2. (p-tolylsulfonyl)imidazole; hydroxylamine hydrochloride; sodium methylate; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00299a044
