(2S,4S,8S,E)-10-((2R,3S,4S,5S,6R)-6-(2-(bromomethyl)-6-(tert-butyldimethylsilyloxy)-3,5-dimethoxy-4-methylphenyl)-4-(tert-butyldimethylsilyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,4,6,8-tetramethyldec-6-en-1ol

Base Information

Chemical Name:(2S,4S,8S,E)-10-((2R,3S,4S,5S,6R)-6-(2-(bromomethyl)-6-(tert-butyldimethylsilyloxy)-3,5-dimethoxy-4-methylphenyl)-4-(tert-butyldimethylsilyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,4,6,8-tetramethyldec-6-en-1ol
CAS No.:1054608-74-0
Molecular Formula:C₄₃H₇₉BrO₆Si₂
Molecular Weight:828.172
Hs Code.:

(2S,4S,8S,E)-10-((2R,3S,4S,5S,6R)-6-(2-(bromomethyl)-6-(tert-butyldimethylsilyloxy)-3,5-dimethoxy-4-methylphenyl)-4-(tert-butyldimethylsilyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,4,6,8-tetramethyldec-6-en-1ol

Synonyms:(2S,4S,8S,E)-10-((2R,3S,4S,5S,6R)-6-(2-(bromomethyl)-6-(tert-butyldimethylsilyloxy)-3,5-dimethoxy-4-methylphenyl)-4-(tert-butyldimethylsilyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,4,6,8-tetramethyldec-6-en-1ol

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Chemical Property of (2S,4S,8S,E)-10-((2R,3S,4S,5S,6R)-6-(2-(bromomethyl)-6-(tert-butyldimethylsilyloxy)-3,5-dimethoxy-4-methylphenyl)-4-(tert-butyldimethylsilyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,4,6,8-tetramethyldec-6-en-1ol

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Technology Process of (2S,4S,8S,E)-10-((2R,3S,4S,5S,6R)-6-(2-(bromomethyl)-6-(tert-butyldimethylsilyloxy)-3,5-dimethoxy-4-methylphenyl)-4-(tert-butyldimethylsilyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,4,6,8-tetramethyldec-6-en-1ol

There total 1 articles about (2S,4S,8S,E)-10-((2R,3S,4S,5S,6R)-6-(2-(bromomethyl)-6-(tert-butyldimethylsilyloxy)-3,5-dimethoxy-4-methylphenyl)-4-(tert-butyldimethylsilyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,4,6,8-tetramethyldec-6-en-1ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1054608-73-9
(3-(bromomethyl)-2-((2R,3S,4S,5S,6R)-4-(tert-butyldimethylsilyloxy)-6-((3S,7S,9S,E)-10-(tert-butyldimethylsilyloxy)-3,5,7,9-tetramethyldec-4-enyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-4,6-dimethoxy-5-methylphenoxy)(tert-butyl)dimethylsilane

: 1054608-74-0
(2S,4S,8S,E)-10-((2R,3S,4S,5S,6R)-6-(2-(bromomethyl)-6-(tert-butyldimethylsilyloxy)-3,5-dimethoxy-4-methylphenyl)-4-(tert-butyldimethylsilyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,4,6,8-tetramethyldec-6-en-1ol

Guidance literature:: With camphor-10-sulfonic acid; In methanol; dichloromethane; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol801499s

Reference yield:

: 1054608-74-0
(2S,4S,8S,E)-10-((2R,3S,4S,5S,6R)-6-(2-(bromomethyl)-6-(tert-butyldimethylsilyloxy)-3,5-dimethoxy-4-methylphenyl)-4-(tert-butyldimethylsilyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,4,6,8-tetramethyldec-6-en-1ol

: 1054608-32-0
C₄₃H₇₇BrO₆Si₂

Guidance literature:: (2S,4S,8S,E)-10-((2R,3S,4S,5S,6R)-6-(2-(bromomethyl)-6-(tert-butyldimethylsilyloxy)-3,5-dimethoxy-4-methylphenyl)-4-(tert-butyldimethylsilyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-2,4,6,8-tetramethyldec-6-en-1ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol801499s