2-[(cyclohexylmethyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine

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Chemical Name:2-[(cyclohexylmethyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine
CAS No.:1050495-44-7
Molecular Formula:C₁₉H₂₉N₅O₃
Molecular Weight:375.471
Hs Code.:

Synonyms:2-[(cyclohexylmethyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine

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Chemical Property of 2-[(cyclohexylmethyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine

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Technology Process of 2-[(cyclohexylmethyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine

There total 7 articles about 2-[(cyclohexylmethyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125552-89-8
4-(bromomethyl)tetrahydro-2H-pyran

: 1050495-42-5
2-[(cyclohexylmethyl)oxy]-8-(methyloxy)-9H-purin-6-amine trifluoroacetate

: 1050495-44-7
2-[(cyclohexylmethyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine

Guidance literature:: 2-[(cyclohexylmethyl)oxy]-8-(methyloxy)-9H-purin-6-amine trifluoroacetate; With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

4-(bromomethyl)tetrahydro-2H-pyran; In N,N-dimethyl-formamide; at 20 - 50 ℃;

Reference yield:

: 5451-40-1
2,6-dichloropurine

: 1050495-44-7
2-[(cyclohexylmethyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / ethyl acetate / 1 h / 50 °C

1.2: 4 h / 60 °C

2.1: sodium t-butanolate / 1,2-dimethoxyethane / 93 °C

3.1: N-Bromosuccinimide / chloroform / 6.25 h / 0 - 20 °C

4.1: 70 °C

5.1: methanol / 18 h / 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

6.2: 20 - 50 °C

With methanol; N-Bromosuccinimide; potassium carbonate; toluene-4-sulfonic acid; sodium t-butanolate; In 1,2-dimethoxyethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1050495-33-4
2-[(cyclohexylmethyl)oxy]-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

: 1050495-44-7
2-[(cyclohexylmethyl)oxy]-8-(methoxy)-9-(tetrahydro-2H-pyran-4-ylmethyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / chloroform / 6.25 h / 0 - 20 °C

2.1: 70 °C

3.1: methanol / 18 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

4.2: 20 - 50 °C

With methanol; N-Bromosuccinimide; potassium carbonate; In chloroform; N,N-dimethyl-formamide;