(L,Z)-2-(5-(3-benzoylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Base Information

Chemical Name:(L,Z)-2-(5-(3-benzoylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid
CAS No.:1436713-98-2
Molecular Formula:C₂₆H₁₉NO₄S₂
Molecular Weight:473.573
Hs Code.:

Synonyms:(L,Z)-2-(5-(3-benzoylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

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Chemical Property of (L,Z)-2-(5-(3-benzoylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

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Technology Process of (L,Z)-2-(5-(3-benzoylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

There total 4 articles about (L,Z)-2-(5-(3-benzoylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 161192-25-2
(S)-2-(4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

: 71856-95-6
3-benzoylbenzaldehyde

: 1436713-98-2
(L,Z)-2-(5-(3-benzoylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Guidance literature:: With Knoevenagel Condensation;
DOI:10.1016/j.bmc.2013.03.041

Reference yield:

: 579-18-0
3-benzoylbenzoic acid

: 1436713-98-2
(L,Z)-2-(5-(3-benzoylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C / Inert atmosphere

3: Dess-Martin periodane / tetrahydrofuran / 4 h / 20 °C

4: Knoevenagel Condensation

With lithium aluminium tetrahydride; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.03.041

Reference yield:

: 52010-96-5
3-(hydroxy(phenyl)methyl)benzaldehyde

: 1436713-98-2
(L,Z)-2-(5-(3-benzoylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / tetrahydrofuran / 4 h / 20 °C

2: Knoevenagel Condensation

With Dess-Martin periodane; In tetrahydrofuran;
DOI:10.1016/j.bmc.2013.03.041