2-tert-[(butoxycarbonyl)amino]-3-{4-[8-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)-8-oxymethyl-8,9-dihydro-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-1-yl]phenyl}propanoic acid ethyl ester radical

Base Information

Chemical Name:2-tert-[(butoxycarbonyl)amino]-3-{4-[8-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)-8-oxymethyl-8,9-dihydro-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-1-yl]phenyl}propanoic acid ethyl ester radical
CAS No.:1310329-32-8
Molecular Formula:C₄₁H₄₈N₅O₆
Molecular Weight:706.862
Hs Code.:

2-tert-[(butoxycarbonyl)amino]-3-{4-[8-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)-8-oxymethyl-8,9-dihydro-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-1-yl]phenyl}propanoic acid ethyl ester radical

Synonyms:2-tert-[(butoxycarbonyl)amino]-3-{4-[8-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)-8-oxymethyl-8,9-dihydro-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-1-yl]phenyl}propanoic acid ethyl ester radical

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Chemical Property of 2-tert-[(butoxycarbonyl)amino]-3-{4-[8-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)-8-oxymethyl-8,9-dihydro-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-1-yl]phenyl}propanoic acid ethyl ester radical

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Technology Process of 2-tert-[(butoxycarbonyl)amino]-3-{4-[8-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)-8-oxymethyl-8,9-dihydro-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-1-yl]phenyl}propanoic acid ethyl ester radical

There total 2 articles about 2-tert-[(butoxycarbonyl)amino]-3-{4-[8-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)-8-oxymethyl-8,9-dihydro-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-1-yl]phenyl}propanoic acid ethyl ester radical which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1152680-15-3
N-Boc 4-azidophenylalanine ethyl ester

: 1310329-31-7
3-[(11,12-didehydro-5,6-dihydrodibenzo[a,e]cycloocten-5-oxy)methyl]-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxyl radical

: 1310329-32-8
2-tert-[(butoxycarbonyl)amino]-3-{4-[8-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)-8-oxymethyl-8,9-dihydro-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-1-yl]phenyl}propanoic acid ethyl ester radical

: C₄₁H₄₈N₅O₆

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2011.03.077

Reference yield:

: 1027338-06-2
4-dibenzocyclooctynol

: 76893-32-8
3-(bromomethyl)-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-oxyl

: 1310329-32-8
2-tert-[(butoxycarbonyl)amino]-3-{4-[8-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)-8-oxymethyl-8,9-dihydro-1H-dibenzo[3,4:7,8]cycloocta[1,2-d][1,2,3]triazol-1-yl]phenyl}propanoic acid ethyl ester radical

: C₄₁H₄₈N₅O₆

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 13 h / 0 - 40 °C

2.1: dichloromethane / 1 h / 20 °C

With sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetlet.2011.03.077