acetic acid 2-[2-acetoxy-3-(6,8-diacetoxy-5-methyl-1-oxo-isochroman-3-yl)-butyl]-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:acetic acid 2-[2-acetoxy-3-(6,8-diacetoxy-5-methyl-1-oxo-isochroman-3-yl)-butyl]-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester
CAS No.:934631-76-2
Molecular Formula:C₄₆H₅₈O₁₂Si
Molecular Weight:831.045
Hs Code.:

acetic acid 2-[2-acetoxy-3-(6,8-diacetoxy-5-methyl-1-oxo-isochroman-3-yl)-butyl]-6-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester

Synonyms:acetic acid 2-[2-acetoxy-3-(6,8-diacetoxy-5-methyl-1-oxo-isochroman-3-yl)-butyl]-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester

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Chemical Property of acetic acid 2-[2-acetoxy-3-(6,8-diacetoxy-5-methyl-1-oxo-isochroman-3-yl)-butyl]-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester

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Technology Process of acetic acid 2-[2-acetoxy-3-(6,8-diacetoxy-5-methyl-1-oxo-isochroman-3-yl)-butyl]-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester

There total 15 articles about acetic acid 2-[2-acetoxy-3-(6,8-diacetoxy-5-methyl-1-oxo-isochroman-3-yl)-butyl]-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3-{3-[6-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3,3-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-1-methyl-propyl}-6,8-dihydroxy-5-methyl-isochroman-1-one

: 108-24-7
acetic anhydride

: 934631-76-2
acetic acid 2-[2-acetoxy-3-(6,8-diacetoxy-5-methyl-1-oxo-isochroman-3-yl)-butyl]-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ol063143k

Reference yield:

: 4,6-bis-methoxymethoxy-2,3-dimethyl-benzaldehyde

: 934631-76-2
acetic acid 2-[2-acetoxy-3-(6,8-diacetoxy-5-methyl-1-oxo-isochroman-3-yl)-butyl]-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH₂PO₄*H₂O; NaClO₂; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O; tetrahydrofuran / 0 °C

2.1: 2.43 g / PPh₃; DIAD / tetrahydrofuran / 0 °C

3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

3.2: 63 percent / tetrahydrofuran / 0.08 h / -100 °C

4.1: catechol borane bromide / CH₂Cl₂ / 1 h / 0 °C

5.1: 75 percent / pyridine / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; bromocatecholborane; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol063143k

Reference yield:

: 4,6-bis-methoxymethoxy-2,3-dimethyl-benzoic acid

: 934631-76-2
acetic acid 2-[2-acetoxy-3-(6,8-diacetoxy-5-methyl-1-oxo-isochroman-3-yl)-butyl]-6-(tert-butyl-diphenyl-silanyloxymethyl)-3,3-dimethyl-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2.43 g / PPh₃; DIAD / tetrahydrofuran / 0 °C

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 63 percent / tetrahydrofuran / 0.08 h / -100 °C

3.1: catechol borane bromide / CH₂Cl₂ / 1 h / 0 °C

4.1: 75 percent / pyridine / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; di-isopropyl azodicarboxylate; bromocatecholborane; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol063143k