1-benzyl-7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Base Information

Chemical Name:1-benzyl-7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one
CAS No.:137022-87-8
Molecular Formula:C₂₅H₂₁Br₂N₃O₂
Molecular Weight:555.269
Hs Code.:

Synonyms:1-benzyl-7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

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Chemical Property of 1-benzyl-7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

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Technology Process of 1-benzyl-7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

There total 17 articles about 1-benzyl-7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 73414-58-1
2-(3,5-dibromo-4-hydroxyphenyl)ethan-1-amine hydrobromide

: 137022-86-7
1-Benzyl-7-methoxy-3,4-dihydro-1H-pyrrolo[4,3,2-de]quinolin-8-one

: 137022-87-8
1-benzyl-7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Guidance literature:: With sodium hydrogencarbonate; In ethanol;
DOI:10.1016/S0040-4039(00)79889-3

Reference yield:

: 22027-96-9
5-nitroveratral

: 137022-87-8
1-benzyl-7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Guidance literature:: Multi-step reaction with 17 steps

1: iron dust, 12 M HCl / methanol / 10 h / Heating

2: Na₂CO₃ / diethyl ether; H₂O / 1.) 0 deg C, 30 min; 2.) room temp., 2 h

3: 93 percent / Jones reagent / acetone / 1.) 0 deg C, 30 min; 2.) room temp., 1 h

4: tetrahydrofuran / 2 h / Ambient temperature

5: 2 M aq. NaN₃ / tetrahydrofuran; H₂O / 2 h / Ambient temperature

6: toluene / 0.5 h / Heating

7: toluene / 2 h / 60 °C

8: 100 percent / hydrogen / 10percent Pd-C / ethanol / 2 h

9: acetonitrile / 1 h

10: NaBH₃CN / acetonitrile / 12 h / 50 °C

11: 85 percent / molecular sieves 3 Angstroem / ethanol / 72 h / Heating

12: 75 percent / 1 M nBu₄NF / tetrahydrofuran / 5 h / Ambient temperature

13: 5 M KOH / methanol / 3 h / Ambient temperature

14: DCC / tetrahydrofuran / Ambient temperature

15: BH₃*SMe₂ / tetrahydrofuran / 5 h / Ambient temperature

16: CAN / acetonitrile; H₂O / 0.08 h

17: 78 percent / NaHCO₃ / ethanol / 3 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium azide; jones reagent; ammonium cerium(IV) nitrate; dimethylsulfide borane complex; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; iron; sodium cyanoborohydride; sodium hydrogencarbonate; sodium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)85065-1

Reference yield:

: 3-amino-4,5-dimethoxy-benzaldehyde

: 137022-87-8
1-benzyl-7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Guidance literature:: Multi-step reaction with 16 steps

1: Na₂CO₃ / diethyl ether; H₂O / 1.) 0 deg C, 30 min; 2.) room temp., 2 h

2: 93 percent / Jones reagent / acetone / 1.) 0 deg C, 30 min; 2.) room temp., 1 h

3: tetrahydrofuran / 2 h / Ambient temperature

4: 2 M aq. NaN₃ / tetrahydrofuran; H₂O / 2 h / Ambient temperature

5: toluene / 0.5 h / Heating

6: toluene / 2 h / 60 °C

7: 100 percent / hydrogen / 10percent Pd-C / ethanol / 2 h

8: acetonitrile / 1 h

9: NaBH₃CN / acetonitrile / 12 h / 50 °C

10: 85 percent / molecular sieves 3 Angstroem / ethanol / 72 h / Heating

11: 75 percent / 1 M nBu₄NF / tetrahydrofuran / 5 h / Ambient temperature

12: 5 M KOH / methanol / 3 h / Ambient temperature

13: DCC / tetrahydrofuran / Ambient temperature

14: BH₃*SMe₂ / tetrahydrofuran / 5 h / Ambient temperature

15: CAN / acetonitrile; H₂O / 0.08 h

16: 78 percent / NaHCO₃ / ethanol / 3 h / Ambient temperature

With potassium hydroxide; sodium azide; jones reagent; ammonium cerium(IV) nitrate; dimethylsulfide borane complex; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; sodium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)85065-1