sodium 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate

Base Information

Chemical Name:sodium 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate
CAS No.:1247823-35-3
Molecular Formula:C₂₃H₁₄ClN₂O₃*Na
Molecular Weight:424.819
Hs Code.:

Synonyms:sodium 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate

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Chemical Property of sodium 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate

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Technology Process of sodium 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate

There total 4 articles about sodium 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1247828-26-7
methyl 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate

: 1247823-35-3
sodium 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 50 ℃; for 1h;
DOI:10.1016/j.bmcl.2017.11.016

Reference yield:

: 585-76-2
m-bromobenzoic acid

: 1247823-35-3
sodium 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; toluene; water / 7.5 h / Inert atmosphere; Reflux

3.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; water; sodium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; water; toluene; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2017.11.016

Reference yield:

: 5202-89-1
4-chlorobenzenesulfonyl chloride

: 1247823-35-3
sodium 5-chloro-2-({[3-(isoquinolin-5-yl)phenyl]carbonyl}amino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; toluene; water / 7.5 h / Inert atmosphere; Reflux

3.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; water; sodium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; water; toluene; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2017.11.016