(2S)-2-(4-methoxy-phenyl)-methyloxy-4-phenyl-sulphonyl-1-(2-tetrahydro-pyranyl)-oxybutane

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Chemical Name:(2S)-2-(4-methoxy-phenyl)-methyloxy-4-phenyl-sulphonyl-1-(2-tetrahydro-pyranyl)-oxybutane
CAS No.:289472-98-6
Molecular Formula:C₂₃H₃₀O₆S
Molecular Weight:434.554
Hs Code.:

Synonyms:(2S)-2-(4-methoxy-phenyl)-methyloxy-4-phenyl-sulphonyl-1-(2-tetrahydro-pyranyl)-oxybutane

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Chemical Property of (2S)-2-(4-methoxy-phenyl)-methyloxy-4-phenyl-sulphonyl-1-(2-tetrahydro-pyranyl)-oxybutane

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Technology Process of (2S)-2-(4-methoxy-phenyl)-methyloxy-4-phenyl-sulphonyl-1-(2-tetrahydro-pyranyl)-oxybutane

There total 4 articles about (2S)-2-(4-methoxy-phenyl)-methyloxy-4-phenyl-sulphonyl-1-(2-tetrahydro-pyranyl)-oxybutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 824-94-2
p-methoxybenzyl chloride

: 289472-97-5
(S)-4-Benzenesulfonyl-1-(tetrahydro-pyran-2-yloxy)-butan-2-ol

: 289472-98-6
(2S)-2-(4-methoxy-phenyl)-methyloxy-4-phenyl-sulphonyl-1-(2-tetrahydro-pyranyl)-oxybutane

Guidance literature:: (S)-4-Benzenesulfonyl-1-(tetrahydro-pyran-2-yloxy)-butan-2-ol; With sodium hydride; In N,N-dimethyl-formamide;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; at 0 - 23 ℃; for 12h;
DOI:10.1016/S0040-4039(00)00715-2

Reference yield:

: 110657-96-0
2-((R)-oxiran-2-ylmethoxy)tetrahydro-2H-pyran

: 289472-98-6
(2S)-2-(4-methoxy-phenyl)-methyloxy-4-phenyl-sulphonyl-1-(2-tetrahydro-pyranyl)-oxybutane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / 0 °C

1.2: 94 percent / HMPA / tetrahydrofuran / -78 - 23 °C

2.1: 85 percent / NaH / dimethylformamide; various solvent(s) / 0 - 23 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo010854h

Reference yield:

: 3112-85-4
methylphenylsulfonate

: 289472-98-6
(2S)-2-(4-methoxy-phenyl)-methyloxy-4-phenyl-sulphonyl-1-(2-tetrahydro-pyranyl)-oxybutane

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / 0 °C

1.2: 94 percent / HMPA / tetrahydrofuran / -78 - 23 °C

2.1: 85 percent / NaH / dimethylformamide; various solvent(s) / 0 - 23 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo010854h