(S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid

Base Information

Chemical Name:(S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid
CAS No.:124344-04-3
Molecular Formula:C₃₆H₅₂N₄O₈
Molecular Weight:668.831
Hs Code.:

(S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid

Synonyms:(S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid

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Chemical Property of (S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid

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Technology Process of (S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid

There total 5 articles about (S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid benzyl ester

: 124344-04-3
(S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2h; under 2585.7 Torr;
DOI:10.1021/jm00167a009

Reference yield:

: 103406-77-5
(2S,4S,5S)-5-Amino-4-(tert-butyl-dimethyl-silanyloxy)-2-isopropyl-7-methyl-octanoic acid {(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butyl}-amide

: 124344-04-3
(S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / Ambient temperature

2: 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / Ambient temperature

3: trifluoroacetic acid (TFA) / CH₂Cl₂ / 1 h / Ambient temperature

4: H₂ / 5percent Pd/C / methanol / 2 h / 2585.7 Torr

With dmap; diethylphosphoryl cyanide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00167a009

Reference yield:

: (S)-N-((1S,2S,4S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-hydroxy-succinamic acid benzyl ester

: 124344-04-3
(S)-N-((1S,2S,4S)-2-Hydroxy-1-isobutyl-5-methyl-4-{(1S,2S)-2-methyl-1-[(pyridin-2-ylmethyl)-carbamoyl]-butylcarbamoyl}-hexyl)-2-phenylacetoxy-succinamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / Ambient temperature

2: trifluoroacetic acid (TFA) / CH₂Cl₂ / 1 h / Ambient temperature

3: H₂ / 5percent Pd/C / methanol / 2 h / 2585.7 Torr

With dmap; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00167a009