[(S)-4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-((2S,4R)-4-benzyl-2-benzylcarbamoyl-pyrrolidine-1-carbonyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Name:[(S)-4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-((2S,4R)-4-benzyl-2-benzylcarbamoyl-pyrrolidine-1-carbonyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
CAS No.:860034-08-8
Molecular Formula:C₅₃H₆₀N₆O₇S
Molecular Weight:925.161
Hs Code.:

[(S)-4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-((2S,4R)-4-benzyl-2-benzylcarbamoyl-pyrrolidine-1-carbonyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Synonyms:[(S)-4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-((2S,4R)-4-benzyl-2-benzylcarbamoyl-pyrrolidine-1-carbonyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of [(S)-4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-((2S,4R)-4-benzyl-2-benzylcarbamoyl-pyrrolidine-1-carbonyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of [(S)-4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-((2S,4R)-4-benzyl-2-benzylcarbamoyl-pyrrolidine-1-carbonyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 3 articles about [(S)-4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-((2S,4R)-4-benzyl-2-benzylcarbamoyl-pyrrolidine-1-carbonyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 860033-48-3
(2S,4R)-4-Benzyl-pyrrolidine-2-carboxylic acid benzylamide

: Pbf-(Fmoc)-Arg-OH

: 860034-08-8
[(S)-4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-((2S,4R)-4-benzyl-2-benzylcarbamoyl-pyrrolidine-1-carbonyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2005.03.120

Reference yield:

: 860033-47-2
(2S,4R)-4-Benzyl-2-benzylcarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 860034-08-8
[(S)-4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-((2S,4R)-4-benzyl-2-benzylcarbamoyl-pyrrolidine-1-carbonyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / TFA / CH₂Cl₂ / 3 h / 20 °C

2: 90 percent / EDCI; HOBt; NMM / dimethylformamide / 4 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.03.120

Reference yield:

: 171038-43-0
ethyl (2S,4R)-N-BOC-4-benzylprolinate

: 860034-08-8
[(S)-4-({Amino-[(E)-2,2,4,6,7-pentamethyl-2,3-dihydro-benzofuran-5-sulfonylimino]-methyl}-amino)-1-((2S,4R)-4-benzyl-2-benzylcarbamoyl-pyrrolidine-1-carbonyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / aq. LiOH / methanol / 18 h / 20 °C

2: EDCI; HOBt; NMM / dimethylformamide / 4 h / 20 °C

3: 100 percent / TFA / CH₂Cl₂ / 3 h / 20 °C

4: 90 percent / EDCI; HOBt; NMM / dimethylformamide / 4 h / 20 °C

With 4-methyl-morpholine; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.03.120