Technology Process of 1-(2,4-dihydroxy-5-methoxyphenyl)-2-(4-hydroxyphenyl)-3,3-dimethoxy-[1,2,3-13C3]-1-propanone
There total 8 articles about 1-(2,4-dihydroxy-5-methoxyphenyl)-2-(4-hydroxyphenyl)-3,3-dimethoxy-[1,2,3-13C3]-1-propanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
5%-palladium/activated carbon;
In
methanol; acetone;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 96 percent / BF3*Et2O / 2 h / 70 °C
2: 94 percent / 18-crown-6; potassium carbonate / acetone / 5 h / Heating
3: 94 percent / KOH / tetrahydrofuran; methanol / 6 h / Heating
4: 97 percent / thallium(III) nitrate trihydrate / methanol / 24 h / 20 °C
5: 93 percent / hydrogen / palladium on charcoal / 20 °C
With
potassium hydroxide; thallium(III) nitrate trihydrate; 18-crown-6 ether; boron trifluoride diethyl etherate; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; acetone;
1: Fries rearrangement;
DOI:10.1016/j.tet.2004.10.028