3-methyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

Base Information

• Chemical Name: 3-methyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide
• CAS No.: 946159-96-2
• Molecular Formula: C₁₃H₁₁F₃N₄S
• Molecular Weight: 312.318
• Mol file: 946159-96-2.mol

Synonyms:3-methyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

Chemical Property of 3-methyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide

There total 4 articles about 3-methyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide (90357-53-2) → 3-methyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide (946159-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / 0 - 70 °C

2: Lawesson's reagent / toluene / Heating

With Lawessons reagent; sodium hydride; In toluene;

DOI:10.1016/j.bmcl.2006.10.035

Reference yield:

3-methyl-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-cyano-3-trifluoromethylphenyl)-amide (888071-40-7) → 3-methyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide (946159-96-2)

Guidance literature:

With Lawessons reagent; In toluene; Heating;

DOI:10.1016/j.bmcl.2006.10.035

Reference yield:

4-amino-2-trifluoromethylbenzonitrile (654-70-6) → 3-methyl-3,4-dihydro-2H-pyrazole-3-carbothioic acid (4-cyano-3-trifluoromethyl-phenyl)-amide (946159-96-2)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / 0 - 20 °C

2: NaH / 0 - 70 °C

3: Lawesson's reagent / toluene / Heating

With Lawessons reagent; thionyl chloride; sodium hydride; In toluene;

DOI:10.1016/j.bmcl.2006.10.035

upstream raw materials:

3-methyl-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-cyano-3-trifluoromethylphenyl)-amide

4-amino-2-trifluoromethylbenzonitrile

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide