2-[bromo(difluoro)methyl]-4,5-dimethylphenyl(pentafluoroethyl)phosphinic acid

Base Information

Chemical Name:2-[bromo(difluoro)methyl]-4,5-dimethylphenyl(pentafluoroethyl)phosphinic acid
CAS No.:1310479-89-0
Molecular Formula:C₁₁H₉BrF₇O₂P
Molecular Weight:417.058
Hs Code.:

Synonyms:2-[bromo(difluoro)methyl]-4,5-dimethylphenyl(pentafluoroethyl)phosphinic acid

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Chemical Property of 2-[bromo(difluoro)methyl]-4,5-dimethylphenyl(pentafluoroethyl)phosphinic acid

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Technology Process of 2-[bromo(difluoro)methyl]-4,5-dimethylphenyl(pentafluoroethyl)phosphinic acid

There total 2 articles about 2-[bromo(difluoro)methyl]-4,5-dimethylphenyl(pentafluoroethyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 354-33-6
1,1,1,2,2-pentafluoroethane

: 1310480-11-5
2-[bromo(difluoro)methyl]-4,5-dimethylphenylphosphonic dichloride

: 1310479-89-0
2-[bromo(difluoro)methyl]-4,5-dimethylphenyl(pentafluoroethyl)phosphinic acid

Guidance literature:: 1,1,1,2,2-pentafluoroethane; With n-butyllithium; In tetrahydrofuran; hexane; at -90 - -80 ℃; for 1h; Inert atmosphere;

2-[bromo(difluoro)methyl]-4,5-dimethylphenylphosphonic dichloride; In tetrahydrofuran; hexane; at -80 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; hexane; at -20 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.076

Reference yield:

: 1310480-07-9
diethyl 2-[bromo(difluoro)methyl]-4,5-dimethylphenylphosphonate

: 1310479-89-0
2-[bromo(difluoro)methyl]-4,5-dimethylphenyl(pentafluoroethyl)phosphinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: phosphorus pentachloride; trichlorophosphate / 4 h / 0 °C / Reflux; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -90 - -80 °C / Inert atmosphere

2.2: -80 - 20 °C / Inert atmosphere

2.3: -20 °C / Inert atmosphere

With n-butyllithium; phosphorus pentachloride; trichlorophosphate; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.03.076