5-FLUORO-8-QUINOLINESULFONYL CHLORIDE

Base Information

• Chemical Name: 5-FLUORO-8-QUINOLINESULFONYL CHLORIDE
• CAS No.: 1997-50-8
• Molecular Formula: C₉H₅ClFNO₂S
• Molecular Weight: 245.662
• Mol file: 1997-50-8.mol

Synonyms:5-FLUORO-8-QUINOLINESULFONYL CHLORIDE

Chemical Property of 5-FLUORO-8-QUINOLINESULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 3.25E-05mmHg at 25°C
• Refractive Index: 1.626
• Boiling Point: 365.6°Cat760mmHg
• Flash Point: 174.9°C
• PSA: 55.41000
• Density: 1.558g/cm³
• LogP: 3.38220

Purity/Quality:

99%min ^*data from raw suppliers

5-Fluoro-8-Quinolinesulfonyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Fluoro-8-Quinolinesulfonyl Chloride may act as a clastogenic compound as well as inhibitor of CYP enzymes due to the quinoline moiety in the substructure. This also leads to antibacterial properties being displayed by the molecule.

Technology Process of 5-FLUORO-8-QUINOLINESULFONYL CHLORIDE

There total 2 articles about 5-FLUORO-8-QUINOLINESULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluoroquinoline (394-69-4) → 5-fluoroquinoline-8-sulfonyl chloride (1997-50-8)

Guidance literature:

With chlorosulfonic acid; at 0 - 130 ℃;

Reference yield:

5-Aminoquinoline (611-34-7,146614-41-7) → 5-fluoroquinoline-8-sulfonyl chloride (1997-50-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; tetrafluoroboric acid / 1 h / 0 °C

2: chlorosulfonic acid / 0 - 130 °C

With chlorosulfonic acid; tetrafluoroboric acid; sodium nitrite;

upstream raw materials:

5-Aminoquinoline

5-fluoroquinoline

Refernces

• 1、 -. "THERAPEUTIC COMPOUNDS AND COMPOSITIONS". . . Retrieved 2014/09/29.