[[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl dihydrogen phosphate

Base Information

Chemical Name:[[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl dihydrogen phosphate
CAS No.:1373128-26-7
Molecular Formula:C₁₉H₁₄F₆N₃O₅P
Molecular Weight:509.301
Hs Code.:

Synonyms:[[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl dihydrogen phosphate

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Chemical Property of [[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl dihydrogen phosphate

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Technology Process of [[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl dihydrogen phosphate

There total 6 articles about [[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1373128-32-5
[[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl bis(1,1-dimethylethyl) phosphate

: 1373128-26-7
[[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl dihydrogen phosphate

Guidance literature:: [[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl bis(1,1-dimethylethyl) phosphate; With water; sodium acetate; acetic acid; In isopropyl alcohol; at 50 - 60 ℃; for 9h; pH=5; Aqueous acetate buffer;

With sodium hydroxide; In water; isopropyl alcohol; at 20 ℃; pH=14;

Reference yield:

: 239087-08-2
2-(bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene

: 1373128-26-7
[[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere

2.2: 0.08 h

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Inert atmosphere

4.1: potassium hydroxide / N,N-dimethyl-formamide / 20 °C / Sealed vial

5.1: sodium acetate; water; acetic acid / isopropyl alcohol / 9 h / 50 - 60 °C / pH 5 / Aqueous acetate buffer

5.2: 20 °C / pH 14

With water; hydrogen; sodium acetate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1373128-29-0
1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-4-nitro-1H-pyrazole

: 1373128-26-7
[[(2,6-difluorophenyl)carbonyl](1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)amino]methyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere

1.2: 0.08 h

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Inert atmosphere

3.1: potassium hydroxide / N,N-dimethyl-formamide / 20 °C / Sealed vial

4.1: sodium acetate; water; acetic acid / isopropyl alcohol / 9 h / 50 - 60 °C / pH 5 / Aqueous acetate buffer

4.2: 20 °C / pH 14

With water; hydrogen; sodium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; potassium hydroxide; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;